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HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Homo sapiens (human) ]

Gene ID: 3326, updated on 5-Jan-2025

Summary

Official Symbol
HSP90AB1provided by HGNC
Official Full Name
heat shock protein 90 alpha family class B member 1provided by HGNC
Primary source
HGNC:HGNC:5258
See related
Ensembl:ENSG00000096384 MIM:140572; AllianceGenome:HGNC:5258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP84; HSPC2; HSPCB; D6S182; HSP90B
Summary
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
Orthologs
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Genomic context

See HSP90AB1 in Genome Data Viewer
Location:
6p21.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44246194..44253883)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44080360..44088031)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44213931..44221620)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene myomixer, myoblast fusion factor Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44181066-44181247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44184149-44185034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44185035-44185920 Neighboring gene Sharpr-MPRA regulatory region 7869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44191161-44192019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24631 Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44194558-44195156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44213140-44213894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44214649-44215403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA 4647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene NFKB inhibitor epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
tat Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
capsid gag Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ26984

Gene Ontology Provided by GOA

Items 1 - 25 of 32
Function Evidence Code Pubs
enables ATP binding  
enables ATP binding PubMed 
enables ATP binding PubMed 
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATP-dependent protein binding PubMed 
enables ATP-dependent protein folding chaperone  
enables DNA polymerase binding PubMed 
enables MHC class II protein complex binding PubMed 
enables RNA binding PubMed 
enables TPR domain binding  
enables cadherin binding PubMed 
enables disordered domain specific binding PubMed 
enables double-stranded RNA binding PubMed 
enables heat shock protein binding PubMed 
enables histone deacetylase binding PubMed 
enables histone methyltransferase binding PubMed 
enables identical protein binding PubMed 
enables kinase binding PubMed 
enables nitric-oxide synthase regulator activity  
enables peptide binding PubMed 
enables protein binding PubMed 
enables protein dimerization activity PubMed 
enables protein folding chaperone PubMed 
enables protein homodimerization activity PubMed 
enables protein kinase binding  
enables protein kinase regulator activity  
enables protein phosphatase activator activity PubMed 
enables receptor ligand inhibitor activity PubMed 
enables tau protein binding PubMed 
enables ubiquitin protein ligase binding PubMed 
enables unfolded protein binding  
Items 1 - 25 of 32
Process Evidence Code Pubs
involved_in cellular response to heat  
involved_in cellular response to interleukin-4  
involved_in chaperone-mediated protein complex assembly PubMed 
involved_in chaperone-mediated protein folding PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of proteasomal protein catabolic process PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
involved_in placenta development  
involved_in positive regulation of cell differentiation PubMed 
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of protein localization to cell surface PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway PubMed 
involved_in protein folding  
involved_in protein stabilization  
involved_in regulation of cell cycle PubMed 
involved_in regulation of protein localization  
involved_in regulation of protein ubiquitination PubMed 
involved_in response to unfolded protein PubMed 
involved_in supramolecular fiber organization PubMed 
involved_in telomerase holoenzyme complex assembly PubMed 
acts_upstream_of_positive_effect telomere maintenance via telomerase PubMed 
involved_in virion attachment to host cell PubMed 
Items 1 - 20 of 29
Component Evidence Code Pubs
part_of COP9 signalosome PubMed 
part_of HSP90-CDC37 chaperone complex PubMed 
part_of aryl hydrocarbon receptor complex PubMed 
located_in axonal growth cone  
located_in cell surface  
located_in cytoplasm PubMed 
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in dendritic growth cone  
located_in dynein axonemal particle  
located_in extracellular exosome PubMed 
located_in extracellular region PubMed 
located_in extracellular region  
located_in ficolin-1-rich granule lumen  
located_in melanosome  
located_in membrane PubMed 
located_in mitochondrion PubMed 
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleus PubMed 
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
part_of protein folding chaperone complex PubMed 
part_of protein-containing complex  
part_of protein-containing complex PubMed 
part_of protein-containing complex PubMed 
located_in secretory granule lumen  
Items 1 - 20 of 29

General protein information

Preferred Names
heat shock protein HSP 90-beta
Names
HSP90-beta
heat shock 84 kDa
heat shock 90kD protein 1, beta
heat shock protein 90 kDa
heat shock protein 90kDa alpha (cytosolic), class B member 1
heat shock protein 90kDa alpha family class B member 1
heat shock protein family C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271969.2NP_001258898.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AY359878, BQ028821
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000325875.3, ENST00000353801.7
    Conserved Domains (1) summary
    PTZ00272
    Location:14724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
  2. NM_001271970.2NP_001258899.1  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_001258899.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, BX420114, DC341882
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000481908.1, ENST00000620073.4
    Conserved Domains (1) summary
    PTZ00272
    Location:14724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
  3. NM_001271971.2NP_001258900.1  heat shock protein HSP 90-beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    BC004928, BE539681, BG482327, DC350708
    UniProtKB/TrEMBL
    B4DGL0
    Conserved Domains (2) summary
    PTZ00272
    Location:14676
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:143666
    HSP90; Hsp90 protein
  4. NM_001271972.2NP_001258901.1  heat shock protein HSP 90-beta isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AK294643, BC007327, BE539681
    UniProtKB/TrEMBL
    B4DGL0
    Conserved Domains (3) summary
    PTZ00272
    Location:14714
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:181704
    HSP90; Hsp90 protein
    pfam02518
    Location:40178
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  5. NM_001371238.1NP_001358167.1  heat shock protein HSP 90-beta isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139392
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000360609.1, ENST00000371554.2
    Conserved Domains (1) summary
    PTZ00272
    Location:14724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
  6. NM_007355.4NP_031381.2  heat shock protein HSP 90-beta isoform a

    See identical proteins and their annotated locations for NP_031381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
    Source sequence(s)
    BC004928, BE539681, DC340766
    Consensus CDS
    CCDS4909.1
    UniProtKB/Swiss-Prot
    B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
    UniProtKB/TrEMBL
    B4DGL0
    Related
    ENSP00000360709.5, ENST00000371646.10
    Conserved Domains (1) summary
    PTZ00272
    Location:14724
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    44246194..44253883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    44080360..44088031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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