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    Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16508, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kcnd2provided by MGI
    Official Full Name
    potassium voltage-gated channel, Shal-related family, member 2provided by MGI
    Primary source
    MGI:MGI:102663
    See related
    Ensembl:ENSMUSG00000060882 AllianceGenome:MGI:102663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv4.2; Gm52855
    Summary
    Enables A-type (transient outward) potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Located in dendritic spine; neuronal cell body; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in cerebellum adult (RPKM 27.7), frontal lobe adult (RPKM 12.3) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kcnd2 in Genome Data Viewer
    Location:
    6 A2- A3.1; 6 8.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21212101..21729804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21215346..21729805)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15298 Neighboring gene STARR-seq mESC enhancer starr_15299 Neighboring gene predicted gene, 23960 Neighboring gene predicted gene, 26373 Neighboring gene STARR-seq mESC enhancer starr_15300 Neighboring gene STARR-seq mESC enhancer starr_15301 Neighboring gene STARR-seq mESC enhancer starr_15302 Neighboring gene STARR-seq mESC enhancer starr_15303 Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene STARR-positive B cell enhancer ABC_E676 Neighboring gene STARR-positive B cell enhancer ABC_E6418 Neighboring gene inhibitor of growth family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1044

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity  
    enables A-type (transient outward) potassium channel activity PubMed 
    enables A-type (transient outward) potassium channel activity PubMed 
    enables A-type (transient outward) potassium channel activity  
    enables A-type (transient outward) potassium channel activity  
    enables metal ion binding  
    enables monoatomic ion channel activity  
    enables potassium channel activity  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables voltage-gated potassium channel activity  
    enables voltage-gated potassium channel activity  
    Process Evidence Code Pubs
    involved_in action potential  
    involved_in action potential  
    involved_in cardiac muscle cell action potential  
    involved_in cardiac muscle cell action potential  
    involved_in cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    involved_in locomotor rhythm PubMed 
    involved_in membrane repolarization  
    involved_in muscle contraction  
    acts_upstream_of_or_within neuronal action potential PubMed 
    involved_in neuronal action potential PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport PubMed 
    involved_in potassium ion transmembrane transport PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in protein homooligomerization  
    involved_in regulation of heart contraction PubMed 
    involved_in regulation of postsynaptic membrane potential  
    involved_in sensory perception of pain PubMed 
    Items 1 - 20 of 40
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    part_of Kv4.2-KChIP2 channel complex  
    located_in T-tubule  
    located_in T-tubule  
    located_in anchoring junction  
    located_in caveola  
    located_in caveola  
    located_in dendrite PubMed 
    located_in dendrite  
    is_active_in dendritic spine  
    located_in dendritic spine PubMed 
    located_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body membrane  
    located_in neuronal cell body membrane  
    located_in perikaryon  
    located_in perinuclear endoplasmic reticulum  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft  
    located_in plasma membrane raft  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    located_in postsynaptic membrane  
    located_in postsynaptic membrane  
    is_active_in postsynaptic specialization membrane PubMed 
    part_of potassium channel complex  
    located_in sarcolemma  
    located_in sarcolemma  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 40

    General protein information

    Preferred Names
    A-type voltage-gated potassium channel KCND2; potassium voltage-gated channel subfamily D member 2
    Names
    voltage-gated potassium channel subunit Kv4.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019697.4NP_062671.1  A-type voltage-gated potassium channel KCND2

      See identical proteins and their annotated locations for NP_062671.1

      Status: VALIDATED

      Source sequence(s)
      BC079667, BY279027, CB520748
      Consensus CDS
      CCDS19934.1
      UniProtKB/Swiss-Prot
      Q8BSK3, Q8CHB7, Q9JJ60, Q9Z0V2
      Related
      ENSMUSP00000080257.6, ENSMUST00000081542.6
      Conserved Domains (6) summary
      smart00225
      Location:43140
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:216415
      Ion_trans; Ion transport protein
      pfam02214
      Location:43132
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331411
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:445546
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      21212101..21729804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165884.1XP_036021777.1  potassium voltage-gated channel subfamily D member 2 isoform X1

      Conserved Domains (2) summary
      cl38908
      Location:6144
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:184373
      Ion_trans; Ion transport protein
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