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    Prox1 prospero homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 19130, updated on 28-Jan-2025

    Summary

    Official Symbol
    Prox1provided by MGI
    Official Full Name
    prospero homeobox 1provided by MGI
    Primary source
    MGI:MGI:97772
    See related
    Ensembl:ENSMUSG00000010175 AllianceGenome:MGI:97772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PROX-1; A230003G05Rik
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye morphogenesis; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including epithelial cell differentiation; hepatocyte cell migration; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and skin. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver adult (RPKM 6.6), heart adult (RPKM 5.0) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Prox1 in Genome Data Viewer
    Location:
    1 H6; 1 95.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189850232..189903024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190118035..190170827, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03414 Neighboring gene predicted gene, 39736 Neighboring gene predicted gene, 30446 Neighboring gene prospero homeobox 1, opposite strand Neighboring gene predicted gene, 39737 Neighboring gene predicted gene, 29678

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding domain binding  
    enables DNA binding domain binding  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables LBD domain binding  
    enables LBD domain binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables nuclear receptor binding  
    enables nuclear receptor binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    acts_upstream_of_or_within acinar cell differentiation PubMed 
    involved_in aorta smooth muscle tissue morphogenesis PubMed 
    involved_in atrial cardiac muscle tissue morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel endothelial cell differentiation PubMed 
    acts_upstream_of_or_within branching involved in pancreas morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cerebellar granule cell differentiation PubMed 
    involved_in circadian rhythm PubMed 
    involved_in dentate gyrus development PubMed 
    involved_in embryonic retina morphogenesis in camera-type eye PubMed 
    involved_in endocardium formation PubMed 
    acts_upstream_of_or_within epithelial cell migration PubMed 
    acts_upstream_of_or_within hepatocyte cell migration PubMed 
    involved_in hepatocyte differentiation PubMed 
    acts_upstream_of_or_within hepatocyte proliferation PubMed 
    acts_upstream_of_or_within inner ear development PubMed 
    involved_in kidney development  
    involved_in lens fiber cell morphogenesis PubMed 
    involved_in lens morphogenesis in camera-type eye PubMed 
    involved_in lens placode formation involved in camera-type eye formation PubMed 
    involved_in lung development  
    acts_upstream_of_or_within lymph vessel development PubMed 
    involved_in lymphangiogenesis  
    involved_in lymphangiogenesis  
    acts_upstream_of_or_within lymphatic endothelial cell differentiation PubMed 
    involved_in lymphatic endothelial cell differentiation  
    involved_in lymphatic endothelial cell fate commitment  
    involved_in lymphatic endothelial cell fate commitment  
    involved_in negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of bile acid biosynthetic process  
    involved_in negative regulation of bile acid biosynthetic process  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of neuroblast proliferation PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of viral genome replication  
    involved_in negative regulation of viral genome replication  
    acts_upstream_of neuroblast proliferation PubMed 
    acts_upstream_of_or_within neuron fate determination PubMed 
    involved_in neuronal stem cell population maintenance PubMed 
    involved_in positive regulation of cell cycle PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle checkpoint PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of forebrain neuron differentiation PubMed 
    involved_in positive regulation of heart growth PubMed 
    involved_in positive regulation of neural precursor cell proliferation PubMed 
    involved_in positive regulation of sarcomere organization PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of gene expression PubMed 
    involved_in regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to nutrient levels  
    involved_in skeletal muscle thin filament assembly PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    involved_in venous blood vessel morphogenesis PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis PubMed 
    involved_in ventricular cardiac myofibril assembly PubMed 
    involved_in ventricular septum morphogenesis PubMed 
    Items 1 - 25 of 69
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    prospero homeobox protein 1
    Names
    homeobox prospero-like protein PROX1
    prospero-related homeobox 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360827.2NP_001347756.1  prospero homeobox protein 1

      Status: VALIDATED

      Source sequence(s)
      AC026911, AC126032
      Consensus CDS
      CCDS35822.1
      UniProtKB/Swiss-Prot
      O88478, P48437, Q3UPV1, Q543D8
      Related
      ENSMUSP00000010319.8, ENSMUST00000010319.14
      Conserved Domains (1) summary
      pfam05044
      Location:579730
      HPD; Homeo-prospero domain
    2. NM_008937.4NP_032963.1  prospero homeobox protein 1

      See identical proteins and their annotated locations for NP_032963.1

      Status: VALIDATED

      Source sequence(s)
      AC026911, AC126032
      Consensus CDS
      CCDS35822.1
      UniProtKB/Swiss-Prot
      O88478, P48437, Q3UPV1, Q543D8
      Related
      ENSMUSP00000135703.2, ENSMUST00000175916.8
      Conserved Domains (1) summary
      pfam05044
      Location:579730
      HPD; Homeo-prospero domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      189850232..189903024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497127.5XP_006497190.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497190.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
    2. XM_036162790.1XP_036018683.1  prospero homeobox protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O88478, P48437, Q3UPV1, Q543D8
      Conserved Domains (1) summary
      pfam05044
      Location:579730
      HPD; Homeo-prospero domain
    3. XM_006497126.5XP_006497189.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497189.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
    4. XM_006497125.5XP_006497188.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497188.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
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