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AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [ Homo sapiens (human) ]

Gene ID: 7965, updated on 4-Jan-2025

Summary

Official Symbol
AIMP2provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2provided by HGNC
Primary source
HGNC:HGNC:20609
See related
Ensembl:ENSG00000106305 MIM:600859; AllianceGenome:HGNC:20609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; JTV1; HLD17; JTV-1
Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in testis (RPKM 18.6), duodenum (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See AIMP2 in Genome Data Viewer
Location:
7p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6009272..6023834)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6127037..6141607)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6048903..6063465)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene radial spoke head 10 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25615 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6065935-6066435 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Leukodystrophy, hypomyelinating, 17
MedGen: C4693912 OMIM: 618006 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in apoptotic process  
involved_in negative regulation of cell population proliferation  
involved_in positive regulation of protein ubiquitination  
involved_in protein ubiquitination  
involved_in protein-containing complex assembly  
involved_in translation  
involved_in type II pneumocyte differentiation  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex  
part_of aminoacyl-tRNA synthetase multienzyme complex PubMed 
located_in cytosol PubMed 
located_in cytosol  
located_in membrane PubMed 
located_in nucleus  

General protein information

Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
ARS-interacting multi-functional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050738.1 RefSeqGene

    Range
    5022..19584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326606.2NP_001313535.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995, CX867709
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:174269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  2. NM_001326607.2NP_001313536.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87475.1
    UniProtKB/TrEMBL
    F8W950
    Related
    ENSP00000378658.2, ENST00000395236.2
  3. NM_001326609.2NP_001313538.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (2) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39130
    Thioredoxin_16; Thioredoxin-like domain
  4. NM_001326610.2NP_001313539.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Related
    ENSP00000383327.2, ENST00000400479.6
    Conserved Domains (2) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39130
    Thioredoxin_16; Thioredoxin-like domain
  5. NM_001326611.3NP_001313540.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995, AI479424, AW131494, CB152528, CX756571
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (2) summary
    cd03200
    Location:136231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39130
    Thioredoxin_16; Thioredoxin-like domain
  6. NM_001362785.2NP_001349714.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:185280
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  7. NM_001362787.2NP_001349716.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:170265
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
  8. NM_006303.4NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform a

    See identical proteins and their annotated locations for NP_006294.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005995, BC002853
    Consensus CDS
    CCDS5344.1
    UniProtKB/Swiss-Prot
    F8W950, Q13155, Q75MR1, Q96CZ5, Q9P1L2
    UniProtKB/TrEMBL
    B2R7M3
    Related
    ENSP00000223029.3, ENST00000223029.8
    Conserved Domains (2) summary
    cd03200
    Location:214309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:133
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6009272..6023834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420835.1XP_047276791.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

    UniProtKB/TrEMBL
    B2R7M3
  2. XM_047420834.1XP_047276790.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

    UniProtKB/TrEMBL
    B2R7M3
  3. XM_005249847.4XP_005249904.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:207302
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6127037..6141607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359001.1XP_054214976.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

    UniProtKB/TrEMBL
    B2R7M3
  2. XM_054359000.1XP_054214975.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

    UniProtKB/TrEMBL
    B2R7M3
  3. XM_054358999.1XP_054214974.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7M3

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