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    Tubb5 tubulin, beta 5 class I [ Mus musculus (house mouse) ]

    Gene ID: 22154, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tubb5provided by MGI
    Official Full Name
    tubulin, beta 5 class Iprovided by MGI
    Primary source
    MGI:MGI:107812
    See related
    Ensembl:ENSMUSG00000001525 AllianceGenome:MGI:107812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M(beta)5; B130022C14Rik
    Summary
    A structural constituent of cytoskeleton. Involved in regulation of synapse organization. Acts upstream of or within spindle assembly. Located in microtubule and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6 and congenital symmetric circumferential skin creases 1. Orthologous to human TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in whole brain E14.5 (RPKM 986.8), CNS E14 (RPKM 862.6) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Tubb5 in Genome Data Viewer
    Location:
    17 B1; 17 18.7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36144812..36149193, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35833920..35838301, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene immediate early response 3 Neighboring gene flotillin 1 Neighboring gene STARR-seq mESC enhancer starr_42478 Neighboring gene STARR-positive B cell enhancer ABC_E5607 Neighboring gene STARR-seq mESC enhancer starr_42479 Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene nurim (nuclear envelope membrane protein)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activating protein binding  
    enables GTPase activating protein binding  
    enables GTPase activity  
    enables MHC class I protein binding  
    enables MHC class I protein binding  
    enables metal ion binding  
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in cell body  
    located_in cell body  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytosol  
    located_in intercellular bridge  
    located_in intercellular bridge  
    located_in membrane raft  
    located_in membrane raft  
    is_active_in microtubule  
    located_in microtubule PubMed 
    located_in microtubule  
    located_in microtubule cytoskeleton  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in nuclear envelope lumen  
    located_in nuclear envelope lumen  
    located_in nucleus PubMed 
    part_of protein-containing complex  
    part_of tubulin complex PubMed 
    Items 1 - 20 of 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011655.5NP_035785.1  tubulin beta-5 chain

      See identical proteins and their annotated locations for NP_035785.1

      Status: VALIDATED

      Source sequence(s)
      AK146567, BY111488, CR974451
      Consensus CDS
      CCDS28706.1
      UniProtKB/Swiss-Prot
      B1B178, P99024, Q3TFB6, Q3THH9, Q3TIL1, Q3UAV4, Q3UF52
      UniProtKB/TrEMBL
      Q3U9U3
      Related
      ENSMUSP00000001566.9, ENSMUST00000001566.10
      Conserved Domains (1) summary
      PLN00220
      Location:1429
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36144812..36149193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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