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    Hspa5 heat shock protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 14828, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hspa5provided by MGI
    Official Full Name
    heat shock protein 5provided by MGI
    Primary source
    MGI:MGI:95835
    See related
    Ensembl:ENSMUSG00000026864 AllianceGenome:MGI:95835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; D2Wsu17e; D2Wsu141e
    Summary
    Enables misfolded protein binding activity; protein folding chaperone; and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cerebellum development; and positive regulation of protein ubiquitination. Acts upstream of or within ER overload response; cellular response to interleukin-4; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 321.6), genital fat pad adult (RPKM 154.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hspa5 in Genome Data Viewer
    Location:
    2 B; 2 22.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34662102..34666541)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34772090..34776529)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene STARR-seq mESC enhancer starr_04265 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene predicted gene, 53241 Neighboring gene STARR-seq mESC enhancer starr_04266 Neighboring gene STARR-seq mESC enhancer starr_04267 Neighboring gene F-box and WD-40 domain protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent protein folding chaperone  
    enables DNA clamp loader activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables enzyme binding  
    enables heat shock protein binding  
    enables misfolded protein binding PubMed 
    enables misfolded protein binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein folding chaperone  
    enables protein folding chaperone PubMed 
    enables protein serine/threonine kinase inhibitor activity  
    enables ribosome binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER overload response PubMed 
    involved_in ERAD pathway  
    involved_in IRE1-mediated unfolded protein response PubMed 
    involved_in cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    acts_upstream_of_or_within cellular response to interleukin-4 PubMed 
    involved_in cerebellar Purkinje cell layer development PubMed 
    involved_in cerebellum structural organization PubMed 
    involved_in chaperone cofactor-dependent protein refolding  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in endoplasmic reticulum unfolded protein response  
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in maintenance of protein localization in endoplasmic reticulum  
    involved_in maintenance of protein localization in endoplasmic reticulum  
    involved_in negative regulation of IRE1-mediated unfolded protein response  
    involved_in negative regulation of PERK-mediated unfolded protein response  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of protein-containing complex assembly  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of embryonic development PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of protein ubiquitination PubMed 
    involved_in post-translational protein targeting to membrane, translocation  
    involved_in post-translational protein targeting to membrane, translocation  
    involved_in protein folding  
    involved_in protein refolding  
    involved_in proteolysis involved in protein catabolic process PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress PubMed 
    Items 1 - 25 of 32
    Items 1 - 20 of 37
    Component Evidence Code Pubs
    part_of COP9 signalosome  
    part_of COP9 signalosome  
    located_in cell surface PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    part_of endoplasmic reticulum chaperone complex  
    part_of endoplasmic reticulum chaperone complex PubMed 
    part_of endoplasmic reticulum chaperone complex  
    is_active_in endoplasmic reticulum lumen  
    located_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum lumen  
    located_in endoplasmic reticulum lumen  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in extracellular region  
    located_in intracellular membrane-bounded organelle  
    located_in melanosome  
    is_active_in membrane  
    located_in membrane PubMed 
    located_in midbody  
    located_in midbody  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in myelin sheath PubMed 
    located_in neuronal cell body  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane PubMed 
    part_of protein-containing complex  
    located_in smooth endoplasmic reticulum  
    Items 1 - 20 of 37

    General protein information

    Preferred Names
    endoplasmic reticulum chaperone BiP
    Names
    78 kDa glucose-regulated protein
    GRP-78
    HSP70 family protein 5
    XAP-1 antigen
    binding-immunoglobulin protein
    glucose regulated protein, 78 kDa
    heat shock 70 kDa protein 5
    heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
    heat shock protein 70 family protein 5
    heat shock protein family A member 5
    immunoglobulin heavy chain-binding protein
    NP_001156906.1
    NP_071705.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163434.1NP_001156906.1  endoplasmic reticulum chaperone BiP precursor

      See identical proteins and their annotated locations for NP_001156906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK148539, AL929106
      Consensus CDS
      CCDS15950.1
      UniProtKB/Swiss-Prot
      O35642, P20029, Q3UFF2, Q61630
      UniProtKB/TrEMBL
      Q3TI47, Q3TKF8, Q3U9G2
      Related
      ENSMUSP00000028222.7, ENSMUST00000028222.13
      Conserved Domains (1) summary
      pfam00012
      Location:31636
      HSP70; Hsp70 protein
    2. NM_022310.3NP_071705.3  endoplasmic reticulum chaperone BiP precursor

      See identical proteins and their annotated locations for NP_071705.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK152521, AL929106
      Consensus CDS
      CCDS15950.1
      UniProtKB/Swiss-Prot
      O35642, P20029, Q3UFF2, Q61630
      UniProtKB/TrEMBL
      Q3TI47, Q3TKF8, Q3U9G2
      Related
      ENSMUSP00000097747.3, ENSMUST00000100171.3
      Conserved Domains (1) summary
      pfam00012
      Location:31636
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34662102..34666541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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