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Frk fyn-related kinase [ Mus musculus (house mouse) ]

Gene ID: 14302, updated on 4-Jan-2025

Summary

Official Symbol
Frkprovided by MGI
Official Full Name
fyn-related kinaseprovided by MGI
Primary source
MGI:MGI:103265
See related
Ensembl:ENSMUSG00000019779 AllianceGenome:MGI:103265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BSK; GTK; RAK; BSK/IYK
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in large intestine adult (RPKM 4.3), placenta adult (RPKM 3.4) and 17 other tissues See more
Orthologs
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Genomic context

See Frk in Genome Data Viewer
Location:
10 B1; 10 18.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34359396..34487530)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34483400..34611232)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26564 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34017128-34017331 Neighboring gene TSPY-like 4 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26275 Neighboring gene collagen, type X, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_26277 Neighboring gene STARR-seq mESC enhancer starr_26278 Neighboring gene STARR-seq mESC enhancer starr_26279 Neighboring gene STARR-seq mESC enhancer starr_26280 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_26281 Neighboring gene STARR-seq mESC enhancer starr_26282 Neighboring gene STARR-seq mESC enhancer starr_26283 Neighboring gene STARR-seq mESC enhancer starr_26284 Neighboring gene survival motor neuron 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
enables protein tyrosine kinase activity  
enables signaling receptor binding  
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in plasma membrane  

General protein information

Preferred Names
tyrosine-protein kinase FRK
Names
B-cell src-homology tyrosine kinase
beta-cell Src-homology tyrosine kinase
intestine tyrosine kinase
NP_001153016.1
NP_001345698.1
NP_034367.2
XP_006512597.1
XP_006512599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159544.1NP_001153016.1  tyrosine-protein kinase FRK

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK052614, AK164460, AK166379, BP761286, CN665865, L36132
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Related
    ENSMUSP00000130289.2, ENSMUST00000170771.3
    Conserved Domains (3) summary
    cd10369
    Location:119214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  2. NM_001358769.1NP_001345698.1  tyrosine-protein kinase FRK

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AC153960, AK052614, AK164460, BP761286
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  3. NM_010237.3NP_034367.2  tyrosine-protein kinase FRK

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK028855, AK164460, AK166379, BP761286
    Consensus CDS
    CCDS23781.1
    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Related
    ENSMUSP00000019913.8, ENSMUST00000019913.15
    Conserved Domains (3) summary
    cd10369
    Location:119214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    34359396..34487530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512534.5XP_006512597.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
  2. XM_006512536.5XP_006512599.1  tyrosine-protein kinase FRK isoform X1

    UniProtKB/Swiss-Prot
    Q61364, Q61745, Q922K9
    Conserved Domains (3) summary
    cd10369
    Location:119214
    SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
    cd11845
    Location:54111
    SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
    cd05068
    Location:232501
    PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
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