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Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306582, updated on 4-Jan-2025

Summary

Official Symbol
Agpat5provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 5provided by RGD
Primary source
RGD:1306405
See related
EnsemblRapid:ENSRNOG00000080701 AllianceGenome:RGD:1306405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306405
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to act upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. Predicted to be located in endoplasmic reticulum membrane; nuclear envelope; and nucleolus. Predicted to be active in endoplasmic reticulum and mitochondrion. Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 82.9), Heart (RPKM 73.0) and 9 other tissues See more
Orthologs
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Genomic context

See Agpat5 in Genome Data Viewer
Location:
16q12.5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77641887..77688148, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70939480..70985745, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75812837..75855996, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pyruvate kinase M1/2 like 1 Neighboring gene XK related 5 Neighboring gene microtubule-associated protein 1 light chain 3 beta 2 Neighboring gene uncharacterized LOC134482416 Neighboring gene microcephalin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Clone Names

  • MGC188222

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in endomembrane system  
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
is_active_in mitochondrion  
located_in mitochondrion  
located_in nuclear envelope  
located_in nucleolus  

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
Names
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
NP_001128216.1
NP_001386354.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134744.2NP_001128216.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZPQ7, A0A8J8YCS6
    Conserved Domains (2) summary
    cd07990
    Location:63258
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:252313
    Acyltransf_C; Acyltransferase C-terminus
  2. NM_001399425.1NP_001386354.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZPQ7, A6IWB3, B4F7C8, G3V965
    Related
    ENSRNOP00000111594.1, ENSRNOT00000154623.1
    Conserved Domains (2) summary
    cd07990
    Location:63264
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:251320
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    77641887..77688148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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