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    Cand1 cullin associated and neddylation disassociated 1 [ Mus musculus (house mouse) ]

    Gene ID: 71902, updated on 13-Jan-2025

    Summary

    Official Symbol
    Cand1provided by MGI
    Official Full Name
    cullin associated and neddylation disassociated 1provided by MGI
    Primary source
    MGI:MGI:1261820
    See related
    Ensembl:ENSMUSG00000020114 AllianceGenome:MGI:1261820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp120a; mKIAA0829; D10Ertd516e; 2310038O07Rik; 6330512O03Rik
    Summary
    Predicted to enable TBP-class protein binding activity. Predicted to be involved in several processes, including SCF complex assembly; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.0), placenta adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cand1 in Genome Data Viewer
    Location:
    10 D2; 10 67.08 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (119034717..119075960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (119198812..119240055, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33982 Neighboring gene predicted gene, 34045 Neighboring gene STARR-seq mESC enhancer starr_28037 Neighboring gene STARR-positive B cell enhancer ABC_E3922 Neighboring gene STARR-positive B cell enhancer ABC_E1815 Neighboring gene STARR-seq mESC enhancer starr_28038 Neighboring gene STARR-seq mESC enhancer starr_28039 Neighboring gene STARR-seq mESC enhancer starr_28040 Neighboring gene STARR-seq mESC enhancer starr_28041 Neighboring gene RIKEN cDNA 4930477N07 gene Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TBP-class protein binding  
    enables TBP-class protein binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in SCF complex assembly  
    involved_in SCF complex assembly  
    involved_in SCF complex assembly  
    involved_in cell differentiation  
    involved_in cell differentiation  
    involved_in negative regulation of catalytic activity  
    involved_in negative regulation of catalytic activity  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    part_of cullin-RING ubiquitin ligase complex  
    part_of cullin-RING ubiquitin ligase complex  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    cullin-associated NEDD8-dissociated protein 1
    Names
    TBP-interacting protein
    cullin-associated and neddylation-dissociated protein 1
    p120 CAND1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027994.1NP_082270.1  cullin-associated NEDD8-dissociated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC160063
      Consensus CDS
      CCDS48701.1
      UniProtKB/Swiss-Prot
      Q6PFR0, Q6ZQ38, Q9CV45
      Related
      ENSMUSP00000020315.7, ENSMUST00000020315.13
      Conserved Domains (4) summary
      cd00020
      Location:650745
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08623
      Location:10401202
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:149202
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:817847
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      119034717..119075960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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