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    Rpt3R Regulatory particle triple-A ATPase 3-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41190, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rpt3Rprovided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 3-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037742
    Locus tag
    Dmel_CG9475
    See related
    AllianceGenome:FB:FBgn0037742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9475; CG9475; DmCG9475; Dmel\CG9475; Dm_Rpt3b; S6
    Summary
    Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in central brain primordium; embryonic brain; fat body/gonad primordium; gonad; and organism. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Rpt3R in Genome Data Viewer
    Location:
    85E6-85E6; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9754735..9756510, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5580457..5582232, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase D3 Neighboring gene Telo2 interacting protein 1 Neighboring gene Alg12 alpha-1,6-mannosyltransferase Neighboring gene Mannose phosphate isomerase Neighboring gene Synaptosomal-associated protein 24kDa

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables proteasome-activating activity  
    enables proteasome-activating activity PubMed 
    Component Evidence Code Pubs
    part_of proteasome regulatory particle, base subcomplex  
    part_of proteasome regulatory particle, base subcomplex  

    General protein information

    Preferred Names
    regulatory particle triple-A ATPase 3-related
    Names
    CG9475-PC
    CG9475-PD
    Rpt3R-PC
    Rpt3R-PD
    NP_649938.2
    NP_731401.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9754735..9756510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169308.4 → NP_731401.3  regulatory particle triple-A ATPase 3-related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731401.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U157, Q9VH79
      Conserved Domains (2) summary
      PTZ00454
      Location:20 → 405
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:189 → 322
      AAA; ATPase family associated with various cellular activities (AAA)
    2. NM_141681.4 → NP_649938.2  regulatory particle triple-A ATPase 3-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U157, Q9VH79
      Conserved Domains (2) summary
      PTZ00454
      Location:20 → 405
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:189 → 322
      AAA; ATPase family associated with various cellular activities (AAA)
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