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SLC39A2 solute carrier family 39 member 2 [ Homo sapiens (human) ]

Gene ID: 29986, updated on 4-Jan-2025

Summary

Official Symbol
SLC39A2provided by HGNC
Official Full Name
solute carrier family 39 member 2provided by HGNC
Primary source
HGNC:HGNC:17127
See related
Ensembl:ENSG00000165794 MIM:612166; AllianceGenome:HGNC:17127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6A1; ZIP2; ETI-1; ZIP-2
Summary
This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]
Expression
Biased expression in skin (RPKM 12.0), esophagus (RPKM 8.3) and 3 other tissues See more
Orthologs
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Genomic context

See SLC39A2 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20999293..21001871)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15196693..15199271)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21467452..21470030)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 107 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8098 Neighboring gene uncharacterized LOC101929718 Neighboring gene methyltransferase like 17 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:21464288-21465487 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21467511-21468710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5576 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ribonuclease A family member 13 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC119190

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule  
located_in cytoplasmic vesicle  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
zinc transporter ZIP2
Names
ZRT/IRT-like protein 2
Zrt- and Irt-like protein 2
solute carrier family 39 (zinc transporter), member 2
zinc transporter 2
zinc uptake transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017065.1 RefSeqGene

    Range
    5039..7617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256588.2NP_001243517.1  zinc transporter ZIP2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and significantly shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AI382710, BC098274, BP359281, CN306082
    Consensus CDS
    CCDS58303.1
    UniProtKB/Swiss-Prot
    Q9NP94
    Related
    ENSP00000452568.1, ENST00000554422.5
    Conserved Domains (1) summary
    cl00437
    Location:574
    Zip; ZIP Zinc transporter
  2. NM_014579.4NP_055394.2  zinc transporter ZIP2 isoform a

    See identical proteins and their annotated locations for NP_055394.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK314974, D83039
    Consensus CDS
    CCDS9563.1
    UniProtKB/Swiss-Prot
    B2RC76, G3V5X2, Q4QQJ1, Q4V9S4, Q96JT6, Q9NP94, Q9UD20
    Related
    ENSP00000298681.4, ENST00000298681.5
    Conserved Domains (1) summary
    pfam02535
    Location:5306
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    20999293..21001871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15196693..15199271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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