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ITGA10 integrin subunit alpha 10 [ Homo sapiens (human) ]

Gene ID: 8515, updated on 4-Jan-2025

Summary

Official Symbol
ITGA10provided by HGNC
Official Full Name
integrin subunit alpha 10provided by HGNC
Primary source
HGNC:HGNC:6135
See related
Ensembl:ENSG00000143127 MIM:604042; AllianceGenome:HGNC:6135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO827
Summary
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in lung (RPKM 2.4), heart (RPKM 1.3) and 22 other tissues See more
Orthologs
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Genomic context

See ITGA10 in Genome Data Viewer
Location:
1q21.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145891208..145910050, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145008042..145026867, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145525030..145543868)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145562391-145562908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145556249-145557232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1268 Neighboring gene uncharacterized LOC107985593 Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145516673-145517219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145516125-145516672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1617 Neighboring gene gonadotropin releasing hormone receptor 2 (pseudogene) Neighboring gene RNA binding motif protein 8A

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding PubMed 
enables collagen binding involved in cell-matrix adhesion PubMed 
enables integrin binding  
enables metal ion binding  
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin  
involved_in cell-cell adhesion  
involved_in cell-matrix adhesion  
involved_in cell-matrix adhesion PubMed 
involved_in cell-matrix adhesion PubMed 
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway PubMed 
involved_in integrin-mediated signaling pathway PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
part_of integrin alpha10-beta1 complex PubMed 
part_of integrin alpha10-beta1 complex PubMed 
part_of integrin complex  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303040.2NP_001289969.1  integrin alpha-10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks three alternate exons in the 5' coding region and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC243547, AF112345, AK304155, BM311010
    UniProtKB/TrEMBL
    B4E282
    Conserved Domains (3) summary
    smart00191
    Location:414468
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:35215
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:511919
    Integrin_alpha2; Integrin alpha
  2. NM_001303041.2NP_001289970.1  integrin alpha-10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001289970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four alternate exons in the 5' coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF112345, BC140831
    Consensus CDS
    CCDS76204.1
    UniProtKB/TrEMBL
    B4E282
    Related
    ENSP00000439894.1, ENST00000539363.2
    Conserved Domains (3) summary
    smart00191
    Location:402456
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:23203
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:499907
    Integrin_alpha2; Integrin alpha
  3. NM_003637.5NP_003628.2  integrin alpha-10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003628.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC243547, AF074015, AF112345
    Consensus CDS
    CCDS72869.1
    UniProtKB/Swiss-Prot
    B2RAM4, B2RTV5, O75578, Q6UXJ6, Q9UHZ8
    UniProtKB/TrEMBL
    B4E2A1
    Related
    ENSP00000358310.3, ENST00000369304.8
    Conserved Domains (3) summary
    smart00191
    Location:545599
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:166346
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6421050
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145891208..145910050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432909.1XP_047288865.1  integrin alpha-10 isoform X8

    UniProtKB/TrEMBL
    B4E2A1
  2. XM_047432895.1XP_047288851.1  integrin alpha-10 isoform X3

    UniProtKB/TrEMBL
    B4E2A1
  3. XM_047432924.1XP_047288880.1  integrin alpha-10 isoform X12

    UniProtKB/TrEMBL
    B4E2A1
  4. XM_047432906.1XP_047288862.1  integrin alpha-10 isoform X7

    UniProtKB/TrEMBL
    B4E2A1
  5. XM_047432904.1XP_047288860.1  integrin alpha-10 isoform X6

    UniProtKB/TrEMBL
    B4E2A1
  6. XM_047432915.1XP_047288871.1  integrin alpha-10 isoform X10

    UniProtKB/TrEMBL
    B4E2A1
  7. XM_017002626.1XP_016858115.1  integrin alpha-10 isoform X11

    UniProtKB/TrEMBL
    B4E282
  8. XM_017002623.1XP_016858112.1  integrin alpha-10 isoform X2

    UniProtKB/TrEMBL
    B4E2A1
  9. XM_047432910.1XP_047288866.1  integrin alpha-10 isoform X9

    UniProtKB/TrEMBL
    B4E2A1
  10. XM_017002625.1XP_016858114.1  integrin alpha-10 isoform X5

    UniProtKB/TrEMBL
    B4E2A1
  11. XM_017002624.1XP_016858113.1  integrin alpha-10 isoform X4

    UniProtKB/TrEMBL
    B4E2A1
  12. XM_017002622.1XP_016858111.1  integrin alpha-10 isoform X1

    UniProtKB/TrEMBL
    B4E2A1
  13. XM_011510083.2XP_011508385.1  integrin alpha-10 isoform X13

    UniProtKB/TrEMBL
    B4E282
    Conserved Domains (3) summary
    smart00191
    Location:380434
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:1181
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:477885
    Integrin_alpha2; Integrin alpha
  14. XM_011510084.1XP_011508386.1  integrin alpha-10 isoform X15

    Conserved Domains (2) summary
    smart00191
    Location:3690
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:133541
    Integrin_alpha2; Integrin alpha
  15. XM_017002627.1XP_016858116.1  integrin alpha-10 isoform X14

RNA

  1. XR_007064482.1 RNA Sequence

  2. XR_001737504.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    145008042..145026867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339308.1XP_054195283.1  integrin alpha-10 isoform X8

    UniProtKB/TrEMBL
    B4E2A1
  2. XM_054339303.1XP_054195278.1  integrin alpha-10 isoform X3

    UniProtKB/TrEMBL
    B4E2A1
  3. XM_054339312.1XP_054195287.1  integrin alpha-10 isoform X12

    UniProtKB/TrEMBL
    B4E2A1
  4. XM_054339307.1XP_054195282.1  integrin alpha-10 isoform X7

    UniProtKB/TrEMBL
    B4E2A1
  5. XM_054339306.1XP_054195281.1  integrin alpha-10 isoform X6

    UniProtKB/TrEMBL
    B4E2A1
  6. XM_054339310.1XP_054195285.1  integrin alpha-10 isoform X10

    UniProtKB/TrEMBL
    B4E2A1
  7. XM_054339311.1XP_054195286.1  integrin alpha-10 isoform X11

    UniProtKB/TrEMBL
    B4E282
  8. XM_054339302.1XP_054195277.1  integrin alpha-10 isoform X2

    UniProtKB/TrEMBL
    B4E2A1
  9. XM_054339309.1XP_054195284.1  integrin alpha-10 isoform X9

    UniProtKB/TrEMBL
    B4E2A1
  10. XM_054339305.1XP_054195280.1  integrin alpha-10 isoform X5

    UniProtKB/TrEMBL
    B4E2A1
  11. XM_054339304.1XP_054195279.1  integrin alpha-10 isoform X4

    UniProtKB/TrEMBL
    B4E2A1
  12. XM_054339301.1XP_054195276.1  integrin alpha-10 isoform X1

    UniProtKB/TrEMBL
    B4E2A1
  13. XM_054339313.1XP_054195288.1  integrin alpha-10 isoform X13

    UniProtKB/TrEMBL
    B4E282
  14. XM_054339315.1XP_054195290.1  integrin alpha-10 isoform X15

  15. XM_054339314.1XP_054195289.1  integrin alpha-10 isoform X14

RNA

  1. XR_008486186.1 RNA Sequence

  2. XR_008486187.1 RNA Sequence

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