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Gata5 GATA binding protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499951, updated on 4-Jan-2025

Summary

Official Symbol
Gata5provided by RGD
Official Full Name
GATA binding protein 5provided by RGD
Primary source
RGD:1561365
See related
EnsemblRapid:ENSRNOG00000058983 AllianceGenome:RGD:1561365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to hydrogen peroxide; cellular response to nitric oxide; and positive regulation of apoptotic DNA fragmentation. Predicted to be located in chromatin and nucleus. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 91.2), Lung (RPKM 39.7) and 1 other tissue See more
Orthologs
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Genomic context

See Gata5 in Genome Data Viewer
Location:
3q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187796140..187804327, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167418563..167426751, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175701278..175709465, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Cdk5 and Abl enzyme substrate 2 Neighboring gene RBBP8 N-terminal like Neighboring gene uncharacterized LOC134486214 Neighboring gene uncharacterized LOC102552888

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in aortic valve morphogenesis  
NOT involved_in cardiac jelly development  
acts_upstream_of_or_within cellular response to BMP stimulus  
involved_in cellular response to hydrogen peroxide PubMed 
involved_in cellular response to nitric oxide PubMed 
involved_in endocardial cushion fusion  
involved_in heart development  
involved_in heart induction  
acts_upstream_of_or_within intestinal epithelial cell differentiation  
involved_in negative regulation of cardiac muscle hypertrophy  
involved_in negative regulation of gene expression  
acts_upstream_of_or_within positive regulation of DNA-templated transcription  
involved_in positive regulation of Notch signaling pathway  
involved_in positive regulation of apoptotic DNA fragmentation PubMed 
involved_in positive regulation of cardiac endothelial to mesenchymal transition  
involved_in positive regulation of gene expression  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within regulation of DNA-templated transcription  
Component Evidence Code Pubs
located_in chromatin  
located_in nucleus  

General protein information

Preferred Names
transcription factor GATA-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024316.1NP_001019487.1  transcription factor GATA-5

    See identical proteins and their annotated locations for NP_001019487.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085855
    UniProtKB/TrEMBL
    A0A0G2K638, A6KMA4, Q5U2V0
    Related
    ENSRNOP00000073661.2, ENSRNOT00000089971.3
    Conserved Domains (3) summary
    smart00401
    Location:245294
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:250300
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1181
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    187796140..187804327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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