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Ak4 adenylate kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 11639, updated on 4-Jan-2025

Summary

Official Symbol
Ak4provided by MGI
Official Full Name
adenylate kinase 4provided by MGI
Primary source
MGI:MGI:87979
See related
Ensembl:ENSMUSG00000028527 AllianceGenome:MGI:87979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak3; AK 4; Ak-3; Ak-4; Ak3l1; D4Ertd274e
Summary
Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Predicted to be involved in nucleoside phosphate metabolic process and regulation of oxidative phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in kidney adult (RPKM 34.8), cerebellum adult (RPKM 9.7) and 13 other tissues See more
Orthologs
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Genomic context

See Ak4 in Genome Data Viewer
Location:
4 C6; 4 46.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101273675..101324968)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101416478..101467771)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene microRNA 101a Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10903 Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene leptin receptor overlapping transcript

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (deoxy)adenylate kinase activity  
enables ATP binding  
enables CMP kinase activity  
enables GTP binding  
enables adenylate kinase activity  
enables adenylate kinase activity  
enables dCMP kinase activity  
enables nucleoside diphosphate kinase activity  
enables nucleoside diphosphate kinase activity  
enables nucleoside diphosphate kinase activity  
enables nucleoside triphosphate adenylate kinase activity  
enables nucleoside triphosphate adenylate kinase activity  
Process Evidence Code Pubs
involved_in ADP biosynthetic process  
involved_in AMP metabolic process  
involved_in AMP metabolic process  
involved_in AMP metabolic process  
involved_in ATP metabolic process  
involved_in ATP metabolic process  
involved_in GTP metabolic process  
involved_in GTP metabolic process  
acts_upstream_of cellular response to hypoxia  
involved_in cellular response to hypoxia  
acts_upstream_of cellular response to hypoxia  
involved_in nucleoside monophosphate phosphorylation  
involved_in nucleoside triphosphate biosynthetic process  
involved_in regulation of oxidative phosphorylation  
involved_in regulation of oxidative phosphorylation  
involved_in ribonucleoside diphosphate biosynthetic process  
involved_in ribonucleoside diphosphate biosynthetic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in mitochondrial matrix  
located_in mitochondrial matrix PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion  

General protein information

Preferred Names
adenylate kinase 4, mitochondrial
Names
ATP-AMP transphosphorylase
GTP:AMP phosphotransferase AK4, mitochondrial
adenylate kinase 3 alpha-like 1
adenylate kinase 3-like 1
adenylate kinase isoenzyme 4, mitochondrial
NP_001171073.1
NP_001171075.1
NP_001171076.1
NP_033777.1
XP_006502748.1
XP_017175412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177602.2NP_001171073.1  adenylate kinase 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001171073.1

    Status: VALIDATED

    Source sequence(s)
    AL845364
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    Q3U489
    Related
    ENSMUSP00000102559.2, ENSMUST00000106946.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7211
    adk; adenylate kinase
  2. NM_001177604.2NP_001171075.1  adenylate kinase 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001171075.1

    Status: VALIDATED

    Source sequence(s)
    AL845364
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    Q3U489
    Related
    ENSMUSP00000102558.2, ENSMUST00000106945.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7211
    adk; adenylate kinase
  3. NM_001177605.2NP_001171076.1  adenylate kinase 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001171076.1

    Status: VALIDATED

    Source sequence(s)
    AL845364
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    Q3U489
    Related
    ENSMUSP00000099841.2, ENSMUST00000102780.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7211
    adk; adenylate kinase
  4. NM_001429549.1NP_001416478.1  adenylate kinase 4, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845364
  5. NM_001429550.1NP_001416479.1  adenylate kinase 4, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845364
    UniProtKB/TrEMBL
    F6TEU8
  6. NM_009647.6NP_033777.1  adenylate kinase 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_033777.1

    Status: VALIDATED

    Source sequence(s)
    AL845364
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    Q3U489
    Conserved Domains (1) summary
    TIGR01351
    Location:7211
    adk; adenylate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101273675..101324968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319923.2XP_017175412.1  adenylate kinase 4, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR01351
    Location:7171
    adk; adenylate kinase
  2. XM_006502685.3XP_006502748.1  adenylate kinase 4, mitochondrial isoform X2

    Related
    ENSMUSP00000121112.2, ENSMUST00000155749.2
    Conserved Domains (1) summary
    TIGR01351
    Location:1139
    adk; adenylate kinase
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