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    Fgf10 fibroblast growth factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 14165, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fgf10provided by MGI
    Official Full Name
    fibroblast growth factor 10provided by MGI
    Primary source
    MGI:MGI:1099809
    See related
    Ensembl:ENSMUSG00000021732 AllianceGenome:MGI:1099809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AEY17; Fgf5a; Fgf-10; Gsfaey17
    Summary
    Enables chemoattractant activity. Involved in positive regulation of DNA-templated transcription and radial glial cell differentiation. Acts upstream of or within several processes, including gland morphogenesis; lung development; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study intestinal atresia and lacrimoauriculodentodigital syndrome 1. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 3.9) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Fgf10 in Genome Data Viewer
    Location:
    13 D2.3; 13 67.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (118851199..118928651)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (118714699..118792573)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10732 Neighboring gene STARR-seq mESC enhancer starr_35794 Neighboring gene Fgf10 5' regulatory region Neighboring gene VISTA enhancer mm917 Neighboring gene predicted gene 16263 Neighboring gene Fgf10 intronic enhancer Neighboring gene STARR-seq mESC enhancer starr_35795 Neighboring gene VISTA enhancer mm605 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35797 Neighboring gene STARR-seq mESC enhancer starr_35799 Neighboring gene STARR-seq mESC enhancer starr_35800 Neighboring gene STARR-seq mESC enhancer starr_35802 Neighboring gene STARR-seq mESC enhancer starr_35803 Neighboring gene STARR-seq mESC enhancer starr_35804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:120196902-120197103 Neighboring gene nicotinamide nucleotide transhydrogenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables chemoattractant activity PubMed 
    enables chemoattractant activity  
    enables fibroblast growth factor receptor binding  
    enables growth factor activity  
    enables growth factor activity  
    enables growth factor activity  
    enables heparin binding  
    enables heparin binding  
    enables protein binding PubMed 
    enables type 2 fibroblast growth factor receptor binding  
    enables type 2 fibroblast growth factor receptor binding  
    enables type 2 fibroblast growth factor receptor binding  
    Items 1 - 25 of 181
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of ERK1 and ERK2 cascade PubMed 
    involved_in ERK1 and ERK2 cascade  
    acts_upstream_of_or_within Harderian gland development PubMed 
    acts_upstream_of Wnt signaling pathway PubMed 
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in angiogenesis  
    acts_upstream_of_or_within animal organ formation PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel remodeling PubMed 
    acts_upstream_of_or_within branch elongation involved in salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
    involved_in branching morphogenesis of an epithelial tube  
    acts_upstream_of_or_within bronchiole morphogenesis PubMed 
    acts_upstream_of_or_within bud elongation involved in lung branching PubMed 
    acts_upstream_of_or_within bud outgrowth involved in lung branching  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cell-cell signaling PubMed 
    acts_upstream_of_or_within cell-cell signaling PubMed 
    acts_upstream_of_or_within chemotaxis PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within digestive tract development PubMed 
    acts_upstream_of_or_within embryonic camera-type eye development PubMed 
    acts_upstream_of_or_within embryonic digestive tract development PubMed 
    acts_upstream_of_or_within embryonic digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within embryonic genitalia morphogenesis PubMed 
    acts_upstream_of_or_within embryonic pattern specification PubMed 
    acts_upstream_of endothelial cell proliferation PubMed 
    acts_upstream_of_or_within epidermis development PubMed 
    acts_upstream_of_or_within epidermis morphogenesis PubMed 
    acts_upstream_of epithelial cell differentiation PubMed 
    acts_upstream_of_or_within epithelial cell differentiation PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    involved_in epithelial cell proliferation  
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis PubMed 
    acts_upstream_of_or_within establishment of mitotic spindle orientation PubMed 
    acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    acts_upstream_of_or_within female genitalia morphogenesis PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor apoptotic signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in mammary gland specification  
    acts_upstream_of fibroblast proliferation PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis PubMed 
    acts_upstream_of_or_within induction of positive chemotaxis PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    acts_upstream_of keratinocyte proliferation PubMed 
    acts_upstream_of_or_within lacrimal gland development PubMed 
    involved_in lacrimal gland development  
    acts_upstream_of_or_within limb bud formation PubMed 
    acts_upstream_of_or_within limb development PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    acts_upstream_of_or_within lung alveolus development PubMed 
    acts_upstream_of_or_within lung alveolus development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within lung epithelium development  
    acts_upstream_of_or_within lung morphogenesis PubMed 
    acts_upstream_of_or_within lung proximal/distal axis specification PubMed 
    involved_in lung saccule development  
    involved_in lung saccule development  
    acts_upstream_of_or_within male genitalia morphogenesis PubMed 
    acts_upstream_of_or_within mammary gland bud formation PubMed 
    acts_upstream_of_or_within mammary gland specification PubMed 
    acts_upstream_of_or_within mesenchymal cell differentiation involved in lung development PubMed 
    acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in lung development PubMed 
    involved_in mesonephros development  
    acts_upstream_of_or_within metanephros morphogenesis PubMed 
    acts_upstream_of mitotic cell cycle PubMed 
    acts_upstream_of_or_within muscle cell fate commitment PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation PubMed 
    involved_in neurogenesis  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within organ growth PubMed 
    acts_upstream_of_or_within organ induction PubMed 
    acts_upstream_of_or_within organ induction  
    acts_upstream_of_or_within otic vesicle formation PubMed 
    involved_in otic vesicle formation PubMed 
    acts_upstream_of_or_within pancreas development PubMed 
    acts_upstream_of_or_within pituitary gland development PubMed 
    involved_in positive chemotaxis  
    acts_upstream_of_or_within positive chemotaxis PubMed 
    acts_upstream_of_or_within positive chemotaxis  
    involved_in positive chemotaxis  
    involved_in positive regulation of ATP-dependent activity  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway PubMed 
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of Ras protein signal transduction  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell migration PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell migration PubMed 
    involved_in positive regulation of epithelial cell migration  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of epithelial cell proliferation  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
    involved_in positive regulation of hair follicle cell proliferation  
    involved_in positive regulation of hair follicle cell proliferation  
    involved_in positive regulation of keratinocyte migration  
    involved_in positive regulation of keratinocyte migration  
    acts_upstream_of_or_within positive regulation of keratinocyte proliferation PubMed 
    involved_in positive regulation of keratinocyte proliferation  
    involved_in positive regulation of lymphocyte proliferation  
    involved_in positive regulation of lymphocyte proliferation  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of urothelial cell proliferation  
    involved_in positive regulation of urothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of white fat cell proliferation PubMed 
    acts_upstream_of_or_within prostatic bud formation PubMed 
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    involved_in radial glial cell differentiation PubMed 
    acts_upstream_of_or_within regulation of activin receptor signaling pathway PubMed 
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling PubMed 
    involved_in regulation of cell migration  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of saliva secretion  
    involved_in regulation of saliva secretion  
    acts_upstream_of_or_within regulation of smoothened signaling pathway PubMed 
    acts_upstream_of_or_within respiratory system development PubMed 
    involved_in response to estradiol  
    involved_in response to lipopolysaccharide  
    involved_in salivary gland development  
    acts_upstream_of_or_within salivary gland morphogenesis PubMed 
    involved_in secretion by lung epithelial cell involved in lung growth  
    involved_in secretion by lung epithelial cell involved in lung growth  
    acts_upstream_of_or_within semicircular canal fusion PubMed 
    acts_upstream_of_or_within semicircular canal morphogenesis PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within spleen development PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of_or_within submandibular salivary gland formation PubMed 
    involved_in tear secretion  
    involved_in tear secretion  
    involved_in thymus development  
    involved_in thymus development  
    acts_upstream_of_or_within thyroid gland development PubMed 
    involved_in tissue regeneration  
    acts_upstream_of_or_within type II pneumocyte differentiation PubMed 
    involved_in urothelial cell proliferation  
    involved_in urothelial cell proliferation  
    acts_upstream_of vascular endothelial growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within white fat cell differentiation PubMed 
    acts_upstream_of white fat cell proliferation PubMed 
    involved_in wound healing  
    involved_in wound healing  
    involved_in wound healing  
    Items 1 - 25 of 181
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cell surface  
    located_in collagen-containing extracellular matrix  
    colocalizes_with collagen-containing extracellular matrix  
    is_active_in cytoplasm  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    fibroblast growth factor 10
    Names
    fibroblast growth factor 5a
    keratinocyte growth factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008002.5NP_032028.1  fibroblast growth factor 10 precursor

      See identical proteins and their annotated locations for NP_032028.1

      Status: VALIDATED

      Source sequence(s)
      AC155244, AC163743
      Consensus CDS
      CCDS26795.1
      UniProtKB/Swiss-Prot
      O35565, Q543V5
      UniProtKB/TrEMBL
      A0A7U3JW48
      Related
      ENSMUSP00000022246.9, ENSMUST00000022246.9
      Conserved Domains (1) summary
      smart00442
      Location:77205
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      118851199..118928651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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