Replication interactions
Interaction |
Pubs |
Knockdown of tubulin, alpha 1c (TUBA1C) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion |
PubMed
|
Envelope surface glycoprotein gp160, precursor
|
env
|
Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 |
PubMed
|
Envelope transmembrane glycoprotein gp41
|
env
|
Expression of HIV-1 gp41 cytoplasmic domain reduces acetylated tubulin alpha and interferes with virus-cell fusion |
PubMed
|
Pr55(Gag)
|
gag
|
Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 |
PubMed
|
Rev
|
rev
|
HIV-1 Rev interacting protein, tubulin alpha 1c (TUBA1C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
PubMed
|
|
rev
|
Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection |
PubMed
|
Tat
|
tat
|
HIV-1 Tat causes a dramatic decrease in alpha-tubulin staining, which indicates disruption of the cytoskeleton organization in human intestinal epithelial cells |
PubMed
|
|
tat
|
HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria |
PubMed
|
|
tat
|
HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim |
PubMed
|
integrase
|
gag-pol
|
Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin |
PubMed
|
Go to the HIV-1, Human Interaction Database