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Kif5b kinesin family member 5B [ Mus musculus (house mouse) ]

Gene ID: 16573, updated on 4-Jan-2025

Summary

Official Symbol
Kif5bprovided by MGI
Official Full Name
kinesin family member 5Bprovided by MGI
Primary source
MGI:MGI:1098268
See related
Ensembl:ENSMUSG00000006740 AllianceGenome:MGI:1098268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Khc; Khcs; Kns1; Ukhc
Summary
Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission; regulation of modification of synapse structure, modulating synaptic transmission; and stress granule disassembly. Acts upstream of or within several processes, including cellular response to type II interferon; mitocytosis; and organelle transport along microtubule. Located in several cellular components, including ciliary rootlet; mitochondrion; and phagocytic vesicle. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in cerebellum adult (RPKM 26.1), bladder adult (RPKM 26.1) and 28 other tissues See more
Orthologs
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Genomic context

See Kif5b in Genome Data Viewer
Location:
18 A1; 18 4.46 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6201005..6241524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6201005..6241524, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 12 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_43701 Neighboring gene predicted gene, 18278 Neighboring gene STARR-positive B cell enhancer ABC_E1514 Neighboring gene STARR-seq mESC enhancer starr_43702 Neighboring gene STARR-seq mESC enhancer starr_43703 Neighboring gene predicted gene, 41664 Neighboring gene STARR-seq mESC enhancer starr_43704 Neighboring gene STARR-seq mESC enhancer starr_43705 Neighboring gene STARR-seq mESC enhancer starr_43706 Neighboring gene STARR-seq mESC enhancer starr_43709 Neighboring gene STARR-seq mESC enhancer starr_43711 Neighboring gene STARR-seq mESC enhancer starr_43712 Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_43713 Neighboring gene prothymosin alpha pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables JUN kinase binding  
enables identical protein binding  
enables identical protein binding  
enables microtubule binding  
enables microtubule binding  
enables microtubule binding  
enables microtubule lateral binding  
enables microtubule motor activity  
enables microtubule motor activity  
enables microtubule motor activity PubMed 
enables plus-end-directed microtubule motor activity  
enables protein binding PubMed 
enables protein-containing complex binding PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in anterograde axonal protein transport  
involved_in anterograde axonal protein transport  
involved_in anterograde dendritic transport of neurotransmitter receptor complex  
involved_in axon guidance  
acts_upstream_of_or_within cellular response to type II interferon PubMed 
involved_in centrosome localization  
involved_in centrosome localization  
acts_upstream_of_or_within cytoplasm organization PubMed 
involved_in lysosome localization  
involved_in lysosome localization  
acts_upstream_of_or_within microtubule-based process PubMed 
acts_upstream_of_or_within mitochondrial transport PubMed 
acts_upstream_of_or_within mitochondrion transport along microtubule PubMed 
acts_upstream_of_or_within mitocytosis PubMed 
involved_in natural killer cell mediated cytotoxicity  
involved_in natural killer cell mediated cytotoxicity  
acts_upstream_of_or_within plus-end-directed vesicle transport along microtubule PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in positive regulation of intracellular protein transport  
involved_in positive regulation of potassium ion transport  
involved_in positive regulation of potassium ion transport  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of synaptic transmission, GABAergic PubMed 
involved_in positive regulation of vesicle fusion  
involved_in regulation of membrane potential  
involved_in regulation of membrane potential  
involved_in regulation of modification of synapse structure, modulating synaptic transmission PubMed 
involved_in regulation of modification of synapse structure, modulating synaptic transmission PubMed 
involved_in retrograde neuronal dense core vesicle transport  
involved_in stress granule disassembly PubMed 
involved_in synaptic vesicle transport  
acts_upstream_of_or_within vesicle transport along microtubule PubMed 
involved_in vesicle transport along microtubule  
involved_in vesicle transport along microtubule  
Items 1 - 25 of 35
Items 1 - 20 of 27
Component Evidence Code Pubs
located_in axon cytoplasm  
located_in axonal growth cone  
located_in centriolar satellite  
located_in centriolar satellite  
located_in ciliary rootlet PubMed 
located_in cytolytic granule membrane  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in endocytic vesicle PubMed 
part_of kinesin complex  
part_of kinesin complex PubMed 
located_in membrane-bounded organelle PubMed 
is_active_in microtubule  
located_in microtubule  
located_in microtubule cytoskeleton  
located_in mitochondrion PubMed 
located_in neuron projection PubMed 
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in phagocytic vesicle PubMed 
is_active_in postsynaptic cytosol PubMed 
is_active_in postsynaptic cytosol PubMed 
is_active_in postsynaptic cytosol PubMed 
located_in vesicle  
located_in vesicle  
Items 1 - 20 of 27

General protein information

Preferred Names
kinesin-1 heavy chain
Names
conventional kinesin heavy chain
kinesin heavy chain member 5B, ubiquitous
ubiquitous kinesin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008448.3NP_032474.2  kinesin-1 heavy chain

    See identical proteins and their annotated locations for NP_032474.2

    Status: VALIDATED

    Source sequence(s)
    AC113003, AI788274, AK014590, AV316286, BC090841
    Consensus CDS
    CCDS37724.1
    UniProtKB/Swiss-Prot
    O08711, Q5BL10, Q61580, Q61768
    Related
    ENSMUSP00000025083.8, ENSMUST00000025083.14
    Conserved Domains (5) summary
    smart00129
    Location:8332
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01369
    Location:6325
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
    pfam05010
    Location:467662
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07851
    Location:598686
    TMPIT; TMPIT-like protein
    pfam14235
    Location:462538
    DUF4337; Domain of unknown function (DUF4337)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    6201005..6241524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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