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Ubox5 U box domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 140629, updated on 4-Jan-2025

Summary

Official Symbol
Ubox5provided by MGI
Official Full Name
U box domain containing 5provided by MGI
Primary source
MGI:MGI:2154658
See related
Ensembl:ENSMUSG00000027300 AllianceGenome:MGI:2154658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP5; Rnf37; Ube7ip5; Ubce7ip5; 1500010O06Rik; C330018L13Rik
Summary
Enables ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ubox5 in Genome Data Viewer
Location:
2 F1; 2 63.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130431916..130471958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130589996..130630038, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxytocin Neighboring gene arginine vasopressin Neighboring gene FAST kinase domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene leucine zipper, putative tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding  
enables ubiquitin protein ligase activity PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin-ubiquitin ligase activity  
enables ubiquitin-ubiquitin ligase activity PubMed 
Component Evidence Code Pubs
located_in focal adhesion  
located_in focal adhesion  
located_in nuclear body  
located_in nuclear body  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
RING finger protein 37
Names
RING-type E3 ubiquitin transferase RNF37
U-box domain-containing protein 5
UbcM4-interacting protein 5
ubiquitin-conjugating enzyme 7-interacting protein 5
NP_001242922.1
NP_001242923.1
NP_542129.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001255993.1NP_001242922.1  RING finger protein 37

    See identical proteins and their annotated locations for NP_001242922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK034114, AK158052, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Conserved Domains (2) summary
    pfam04564
    Location:259337
    U-box; U-box domain
    pfam14634
    Location:484527
    zf-RING_5; zinc-RING finger domain
  2. NM_001255994.1NP_001242923.1  RING finger protein 37

    See identical proteins and their annotated locations for NP_001242923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AF360997, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Related
    ENSMUSP00000028761.5, ENSMUST00000028761.5
    Conserved Domains (2) summary
    pfam04564
    Location:259337
    U-box; U-box domain
    pfam14634
    Location:484527
    zf-RING_5; zinc-RING finger domain
  3. NM_080562.5NP_542129.2  RING finger protein 37

    See identical proteins and their annotated locations for NP_542129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK034114, AL731707, AW060426
    Consensus CDS
    CCDS16747.1
    UniProtKB/Swiss-Prot
    Q925F4
    UniProtKB/TrEMBL
    Q3TZ72, Q543N0
    Conserved Domains (2) summary
    pfam04564
    Location:259337
    U-box; U-box domain
    pfam14634
    Location:484527
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130431916..130471958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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