U.S. flag

An official website of the United States government

MRPL17 mitochondrial ribosomal protein L17 [ Homo sapiens (human) ]

Gene ID: 63875, updated on 4-Jan-2025

Summary

Official Symbol
MRPL17provided by HGNC
Official Full Name
mitochondrial ribosomal protein L17provided by HGNC
Primary source
HGNC:HGNC:14053
See related
Ensembl:ENSG00000158042 MIM:611830; AllianceGenome:HGNC:14053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIP2; L17mt; bL17m; RPL17L; RPML26; MRP-L17; MRP-L26
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 11.3), placenta (RPKM 10.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MRPL17 in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6680385..6683340, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6738851..6741807, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6701616..6704571, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4351 Neighboring gene tripeptidyl peptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4352 Neighboring gene dachsous cadherin-related 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6662561-6663130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6668387-6668887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6704113-6704875 Neighboring gene NANOG hESC enhancer GRCh37_chr11:6711804-6712353 Neighboring gene ribosomal protein L21 pseudogene 94 Neighboring gene uncharacterized LOC124902625

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L17 (MRPL17) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables structural constituent of ribosome  

General protein information

Preferred Names
large ribosomal subunit protein bL17m
Names
39S ribosomal protein L17, mitochondrial
LYST-interacting protein 2
LYST-interacting protein LIP2
mitochondrial large ribosomal subunit protein bL17m

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022061.4NP_071344.1  large ribosomal subunit protein bL17m

    Status: REVIEWED

    Source sequence(s)
    AF164797, AL572779, BF513148, BM725086, DA876701, DB228622
    Consensus CDS
    CCDS31412.1
    UniProtKB/Swiss-Prot
    D3DQU3, Q6IAH8, Q96Q53, Q9C066, Q9NRX2
    UniProtKB/TrEMBL
    E9PKV2
    Related
    ENSP00000288937.6, ENST00000288937.7
    Conserved Domains (1) summary
    pfam01196
    Location:28125
    Ribosomal_L17; Ribosomal protein L17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6680385..6683340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6738851..6741807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.