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Lpar1 lysophosphatidic acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14745, updated on 4-Jan-2025

Summary

Official Symbol
Lpar1provided by MGI
Official Full Name
lysophosphatidic acid receptor 1provided by MGI
Primary source
MGI:MGI:108429
See related
Ensembl:ENSMUSG00000038668 AllianceGenome:MGI:108429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg2; Kdt2; lpA1; vzg-1; Gpcr26
Summary
Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.9), colon adult (RPKM 17.1) and 24 other tissues See more
Orthologs
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Genomic context

See Lpar1 in Genome Data Viewer
Location:
4 B3; 4 32.2 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58435252..58554601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58435252..58554027, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30907 Neighboring gene STARR-seq mESC enhancer starr_10356 Neighboring gene muscle, skeletal, receptor tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_10357 Neighboring gene STARR-seq mESC enhancer starr_10358 Neighboring gene microRNA 3095 Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10361 Neighboring gene predicted gene, 54282 Neighboring gene predicted gene 12579 Neighboring gene STARR-seq mESC enhancer starr_10362 Neighboring gene STARR-seq mESC enhancer starr_10364 Neighboring gene STARR-seq mESC enhancer starr_10365 Neighboring gene olfactory receptor family 2 subfamily K member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC29102, 5031439C20

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding  
enables G-protein alpha-subunit binding  
enables PDZ domain binding PubMed 
enables lysophosphatidic acid binding  
enables lysophosphatidic acid binding  
enables lysophosphatidic acid receptor activity  
enables lysophosphatidic acid receptor activity PubMed 
enables lysophosphatidic acid receptor activity  
enables phospholipid binding  
enables protein binding PubMed 
Items 1 - 25 of 45
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within bleb assembly PubMed 
involved_in cell chemotaxis  
involved_in cell chemotaxis  
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate  
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate  
involved_in cellular response to oxygen levels  
involved_in cerebellum development  
involved_in corpus callosum development  
involved_in myelination  
involved_in negative regulation of cAMP-mediated signaling  
involved_in negative regulation of cAMP-mediated signaling  
involved_in negative regulation of cilium assembly  
involved_in negative regulation of cilium assembly  
involved_in negative regulation of neuron projection development PubMed 
involved_in negative regulation of neuron projection development PubMed 
involved_in negative regulation of neuron projection development  
involved_in neurogenesis  
involved_in oligodendrocyte development  
involved_in optic nerve development  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
involved_in positive regulation of MAPK cascade PubMed 
acts_upstream_of_or_within positive regulation of Rho protein signal transduction PubMed 
involved_in positive regulation of Rho protein signal transduction PubMed 
involved_in positive regulation of Rho protein signal transduction PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of dendritic spine development  
involved_in positive regulation of dendritic spine development  
involved_in positive regulation of smooth muscle cell chemotaxis  
involved_in positive regulation of smooth muscle cell chemotaxis  
involved_in positive regulation of stress fiber assembly PubMed 
involved_in regulation of cell shape PubMed 
involved_in regulation of cell shape PubMed 
involved_in regulation of metabolic process  
involved_in regulation of postsynaptic neurotransmitter receptor internalization  
involved_in regulation of postsynaptic neurotransmitter receptor internalization  
involved_in regulation of synaptic vesicle cycle  
involved_in regulation of synaptic vesicle cycle  
Items 1 - 25 of 45
Items 1 - 20 of 24
Component Evidence Code Pubs
located_in GABA-ergic synapse  
is_active_in GABA-ergic synapse  
located_in cell surface  
located_in cell surface  
is_active_in cytoplasm  
located_in dendritic shaft  
located_in dendritic shaft  
located_in dendritic spine  
located_in dendritic spine  
located_in endocytic vesicle  
colocalizes_with endocytic vesicle  
located_in endosome  
located_in endosome  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in neuronal cell body  
located_in neuronal cell body  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynaptic membrane  
is_active_in postsynaptic membrane  
located_in presynaptic membrane  
is_active_in presynaptic membrane  
Items 1 - 20 of 24

General protein information

Preferred Names
lysophosphatidic acid receptor 1
Names
G-protein coupled receptor 26
LPA receptor 1
endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2
lysophosphatidic acid receptor Edg-2
rec1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290486.2NP_001277415.1  lysophosphatidic acid receptor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807748
    Consensus CDS
    CCDS71391.1
    UniProtKB/Swiss-Prot
    P61793
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000103196.2, ENSMUST00000107570.2
    Conserved Domains (1) summary
    cd15344
    Location:32304
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001421009.1NP_001407938.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  3. NM_001421010.1NP_001407939.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  4. NM_001421011.1NP_001407940.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  5. NM_001421012.1NP_001407941.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  6. NM_001421013.1NP_001407942.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  7. NM_001421014.1NP_001407943.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  8. NM_001421015.1NP_001407944.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  9. NM_001421016.1NP_001407945.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
  10. NM_010336.2NP_034466.2  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_034466.2

    Status: VALIDATED

    Source sequence(s)
    AK030330, AL807748, CJ152526
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000103201.3, ENSMUST00000107575.9
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  11. NM_172989.2NP_766577.1  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_766577.1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000052581.5, ENSMUST00000055018.11
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58435252..58554601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253215.2XP_030109075.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011249932.4XP_011248234.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248234.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_036163685.1XP_036019578.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011249930.3XP_011248232.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248232.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011249933.4XP_011248235.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248235.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_036163686.1XP_036019579.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
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