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Mark1 MAP/microtubule affinity regulating kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 226778, updated on 13-Jan-2025

Summary

Official Symbol
Mark1provided by MGI
Official Full Name
MAP/microtubule affinity regulating kinase 1provided by MGI
Primary source
MGI:MGI:2664902
See related
Ensembl:ENSMUSG00000026620 AllianceGenome:MGI:2664902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emk3; Par-1c; mPar-1c; mKIAA1477; B930025N23Rik
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and phospholipid binding activity. Involved in establishment of mitochondrion localization; regulation of dendrite development; and regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human MARK1 (microtubule affinity regulating kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E18 (RPKM 14.7), whole brain E14.5 (RPKM 14.5) and 19 other tissues See more
Orthologs
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Genomic context

See Mark1 in Genome Data Viewer
Location:
1 H5; 1 89.26 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184628621..184732152, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184896424..184999954, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130074G19 gene Neighboring gene predicted gene, 34602 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 39728 Neighboring gene STARR-seq mESC enhancer starr_03320 Neighboring gene predicted gene, 34732 Neighboring gene STARR-seq mESC enhancer starr_03321 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Interactions

General gene information

Clone Names

  • KIAA1477

Gene Ontology Provided by MGI

Items 1 - 25 of 37
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables magnesium ion binding  
enables magnesium ion binding  
enables phosphatidic acid binding  
enables phosphatidic acid binding  
enables phosphatidylinositol-4,5-bisphosphate binding  
enables phosphatidylinositol-4,5-bisphosphate binding  
enables phosphatidylserine binding  
enables phosphatidylserine binding  
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
enables tau-protein kinase activity  
enables tau-protein kinase activity  
Items 1 - 25 of 37
Process Evidence Code Pubs
involved_in Wnt signaling pathway  
involved_in chromatin remodeling  
involved_in cytoskeleton organization  
involved_in establishment of mitochondrion localization PubMed 
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in negative regulation of epithelial to mesenchymal transition  
involved_in negative regulation of epithelial to mesenchymal transition  
involved_in negative regulation of gene expression  
acts_upstream_of negative regulation of gene expression  
involved_in neuron migration  
involved_in neuron migration  
involved_in positive regulation of gene expression  
acts_upstream_of positive regulation of gene expression  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in regulation of dendrite development PubMed 
involved_in regulation of neuron projection development PubMed 
involved_in regulation of postsynapse assembly PubMed 
involved_in regulation of postsynapse assembly PubMed 
involved_in regulation of postsynapse assembly PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoskeleton  
located_in cytoskeleton  
located_in dendrite  
located_in dendrite  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in plasma membrane  
located_in plasma membrane  
is_active_in postsynapse PubMed 
is_active_in postsynapse PubMed 
is_active_in postsynapse PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase MARK1
Names
ELKL motif serine-threonine protein kinase 3
PAR1 homolog c
NP_001365805.1
NP_663490.2
XP_006497203.1
XP_006497204.1
XP_030109398.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378876.1NP_001365805.1  serine/threonine-protein kinase MARK1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117826, AC131992
    UniProtKB/TrEMBL
    C9K101
    Conserved Domains (3) summary
    cd12196
    Location:697794
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331371
    UBA_like_SF; UBA domain-like superfamily
  2. NM_145515.2NP_663490.2  serine/threonine-protein kinase MARK1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131992, AK047140, AK173181, BC112400, CJ179387, CX210969
    Consensus CDS
    CCDS35817.1
    UniProtKB/Swiss-Prot
    E9QL17, Q69ZI7, Q8VHJ5
    UniProtKB/TrEMBL
    Q14DQ3
    Related
    ENSMUSP00000027929.5, ENSMUST00000027929.10
    Conserved Domains (3) summary
    cd12196
    Location:696793
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331371
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    184628621..184732152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497140.5XP_006497203.1  serine/threonine-protein kinase MARK1 isoform X1

    UniProtKB/TrEMBL
    C9K101
    Conserved Domains (3) summary
    cd12196
    Location:682779
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331371
    UBA_like_SF; UBA domain-like superfamily
  2. XM_030253538.1XP_030109398.1  serine/threonine-protein kinase MARK1 isoform X3

    Conserved Domains (3) summary
    cd12196
    Location:417514
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cl21453
    Location:132
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:5292
    UBA_like_SF; UBA domain-like superfamily
  3. XM_006497141.5XP_006497204.1  serine/threonine-protein kinase MARK1 isoform X2

    UniProtKB/TrEMBL
    Q14DQ3
    Conserved Domains (3) summary
    cd12196
    Location:681778
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:59311
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:331371
    UBA_like_SF; UBA domain-like superfamily
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