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Tulp3 TUB like protein 3 [ Mus musculus (house mouse) ]

Gene ID: 22158, updated on 4-Jan-2025

Summary

Official Symbol
Tulp3provided by MGI
Official Full Name
TUB like protein 3provided by MGI
Primary source
MGI:MGI:1329045
See related
Ensembl:ENSMUSG00000001521 AllianceGenome:MGI:1329045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310022L06Rik
Summary
Predicted to enable several functions, including enzyme binding activity; intraciliary transport particle A binding activity; and phosphatidylinositol binding activity. Involved in protein localization to cilium. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and skeletal system development. Located in axoneme. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Used to study polycystic kidney disease. Orthologous to human TULP3 (TUB like protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.2), ovary adult (RPKM 13.2) and 27 other tissues See more
Orthologs
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Genomic context

See Tulp3 in Genome Data Viewer
Location:
6 F3; 6 62.96 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128298103..128332833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128321140..128355873, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TEA domain family member 4 Neighboring gene STARR-seq mESC enhancer starr_17434 Neighboring gene STARR-positive B cell enhancer ABC_E8134 Neighboring gene ribosomal protein L18, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E4867 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene testis expressed 52

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding PubMed 
enables enzyme binding  
enables enzyme binding  
enables intraciliary transport particle A binding PubMed 
enables intraciliary transport particle A binding  
enables phosphatidylinositol binding  
enables phosphatidylinositol binding  
enables protein-containing complex binding  
Items 1 - 25 of 28
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
acts_upstream_of_or_within bone development PubMed 
acts_upstream_of_or_within brain development PubMed 
acts_upstream_of_or_within bronchus morphogenesis PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
acts_upstream_of_or_within embryonic camera-type eye development PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
acts_upstream_of_or_within embryonic neurocranium morphogenesis PubMed 
acts_upstream_of_or_within ganglion development PubMed 
acts_upstream_of_or_within limb development PubMed 
acts_upstream_of_or_within limb development PubMed 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway PubMed 
involved_in negative regulation of smoothened signaling pathway  
acts_upstream_of_or_within neural tube closure PubMed 
acts_upstream_of_or_within neural tube development PubMed 
acts_upstream_of_or_within neural tube formation PubMed 
involved_in protein localization to cilium  
acts_upstream_of_or_within protein localization to cilium PubMed 
involved_in protein localization to cilium PubMed 
acts_upstream_of_or_within protein localization to cilium PubMed 
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway  
involved_in regulation of G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within regulation of smoothened signaling pathway PubMed 
acts_upstream_of smoothened signaling pathway PubMed 
acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning PubMed 
Items 1 - 25 of 28
Component Evidence Code Pubs
located_in 9+0 non-motile cilium  
located_in axoneme PubMed 
located_in ciliary base  
is_active_in cilium  
located_in cilium PubMed 
located_in cilium PubMed 
located_in extracellular region  
located_in nucleolus  
located_in nucleolus  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  
located_in plasma membrane PubMed 

General protein information

Preferred Names
tubby-related protein 3
Names
tubby-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011657.2NP_035787.1  tubby-related protein 3

    See identical proteins and their annotated locations for NP_035787.1

    Status: VALIDATED

    Source sequence(s)
    BC060068, BY347356
    Consensus CDS
    CCDS39647.1
    UniProtKB/Swiss-Prot
    O88413
    Related
    ENSMUSP00000001562.7, ENSMUST00000001562.9
    Conserved Domains (2) summary
    pfam01167
    Location:213453
    Tub; Tub family
    pfam16322
    Location:30173
    Tub_N; Tubby N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128298103..128332833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003956188.2 RNA Sequence

  2. XR_003956187.2 RNA Sequence

  3. XR_004942936.1 RNA Sequence

  4. XR_004942937.1 RNA Sequence

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