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    Fuz fuzzy planar cell polarity protein [ Mus musculus (house mouse) ]

    Gene ID: 70300, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fuzprovided by MGI
    Official Full Name
    fuzzy planar cell polarity proteinprovided by MGI
    Primary source
    MGI:MGI:1917550
    See related
    Ensembl:ENSMUSG00000011658 AllianceGenome:MGI:1917550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b1273Clo; 2600013E07Rik
    Summary
    Enables phosphatidylinositol binding activity. Involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regionalization. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including central nervous system; neural ectoderm; and notochord. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 71.2), ovary adult (RPKM 43.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Fuz in Genome Data Viewer
    Location:
    7 B3; 7 28.99 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44545517..44552053)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44894305..44900624)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 42
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within aorta development PubMed 
    acts_upstream_of_or_within cardiac septum development PubMed 
    acts_upstream_of_or_within cilium assembly PubMed 
    involved_in cilium assembly PubMed 
    acts_upstream_of_or_within coronary vasculature development PubMed 
    involved_in embryonic body morphogenesis PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis PubMed 
    involved_in embryonic skeletal system morphogenesis PubMed 
    involved_in establishment of planar polarity PubMed 
    involved_in establishment of planar polarity PubMed 
    involved_in hair follicle development PubMed 
    involved_in intraciliary transport PubMed 
    acts_upstream_of_or_within larynx morphogenesis PubMed 
    acts_upstream_of_or_within larynx morphogenesis PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation PubMed 
    involved_in negative regulation of neural crest formation PubMed 
    acts_upstream_of_or_within neural tube closure PubMed 
    involved_in neural tube closure PubMed 
    involved_in neural tube closure  
    involved_in neural tube development PubMed 
    involved_in non-motile cilium assembly  
    involved_in non-motile cilium assembly PubMed 
    involved_in non-motile cilium assembly  
    involved_in positive regulation of cilium assembly PubMed 
    involved_in positive regulation of cilium assembly  
    acts_upstream_of_or_within positive regulation of protein processing PubMed 
    involved_in protein transport  
    involved_in regulation of cilium assembly PubMed 
    acts_upstream_of_or_within regulation of smoothened signaling pathway PubMed 
    involved_in regulation of smoothened signaling pathway PubMed 
    acts_upstream_of_or_within roof of mouth development PubMed 
    acts_upstream_of_or_within spinal cord development PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning PubMed 
    acts_upstream_of_or_within tongue morphogenesis PubMed 
    involved_in vesicle-mediated transport  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    located_in cilium PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  

    General protein information

    Preferred Names
    protein fuzzy homolog
    Names
    fuzzy homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403450.1NP_001390379.1  protein fuzzy homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      Q3UYI6, Q9D0P9
    2. NM_001403451.1NP_001390380.1  protein fuzzy homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/TrEMBL
      A0A140LIC9
      Related
      ENSMUST00000208291.2
    3. NM_001403452.1NP_001390381.1  protein fuzzy homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      Q3UYI6, Q9D0P9
    4. NM_001403453.1NP_001390382.1  protein fuzzy homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/Swiss-Prot
      Q3UYI6, Q9D0P9
      UniProtKB/TrEMBL
      A0A140LI55
      Related
      ENSMUSP00000146681.2, ENSMUST00000209039.2
    5. NM_001403454.1NP_001390383.1  protein fuzzy homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/TrEMBL
      A0A140LJD3
      Related
      ENSMUSP00000147169.2, ENSMUST00000207485.2
    6. NM_001403455.1NP_001390384.1  protein fuzzy homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/TrEMBL
      A0A140LI68
    7. NM_001403456.1NP_001390385.1  protein fuzzy homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/TrEMBL
      A0A140LI68
      Related
      ENSMUSP00000146434.2, ENSMUST00000209132.2
    8. NM_001403457.1NP_001390386.1  protein fuzzy homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158231
      UniProtKB/TrEMBL
      A0A140LI92
      Related
      ENSMUSP00000146725.2, ENSMUST00000208908.2
    9. NM_027376.4NP_081652.2  protein fuzzy homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS52237.1
      UniProtKB/Swiss-Prot
      Q3UYI6, Q9D0P9
      UniProtKB/TrEMBL
      E9QL29
      Related
      ENSMUSP00000071194.8, ENSMUST00000071207.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44545517..44552053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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