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Fto FTO alpha-ketoglutarate dependent dioxygenase [ Mus musculus (house mouse) ]

Gene ID: 26383, updated on 13-Jan-2025

Summary

Official Symbol
Ftoprovided by MGI
Official Full Name
FTO alpha-ketoglutarate dependent dioxygenaseprovided by MGI
Primary source
MGI:MGI:1347093
See related
Ensembl:ENSMUSG00000055932 AllianceGenome:MGI:1347093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1752
Summary
Enables broad specificity oxidative DNA demethylase activity and oxidative RNA demethylase activity. Involved in several processes, including DNA alkylation repair; RNA repair; and regulation of respiratory system process. Located in nucleus. Is expressed in several structures, including alimentary system; cerebral cortex; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 30.4) and 28 other tissues See more
Orthologs
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Genomic context

See Fto in Genome Data Viewer
Location:
8 C5; 8 44.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (92039995..92395061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91313367..91668433)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene abhydrolase domain containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22299 Neighboring gene predicted gene, 36163 Neighboring gene RIKEN cDNA 4831440D22 gene Neighboring gene STARR-seq mESC enhancer starr_22306 Neighboring gene STARR-seq mESC enhancer starr_22308 Neighboring gene uncharacterized LOC118567558 Neighboring gene STARR-seq mESC enhancer starr_22309 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity PubMed 
enables broad specificity oxidative DNA demethylase activity  
enables broad specificity oxidative DNA demethylase activity PubMed 
enables broad specificity oxidative DNA demethylase activity  
enables ferrous iron binding  
enables ferrous iron binding  
enables ferrous iron binding  
enables mRNA N6-methyladenosine dioxygenase activity  
enables mRNA N6-methyladenosine dioxygenase activity  
enables mRNA N6-methyladenosine dioxygenase activity  
enables oxidative RNA demethylase activity PubMed 
enables oxidative RNA demethylase activity  
enables tRNA demethylase activity  
enables tRNA demethylase activity  
Process Evidence Code Pubs
involved_in DNA alkylation repair PubMed 
involved_in DNA alkylation repair  
involved_in RNA repair PubMed 
involved_in RNA repair  
involved_in adipose tissue development PubMed 
involved_in mRNA destabilization  
involved_in mRNA destabilization  
involved_in negative regulation of eating behavior  
involved_in osteoblast differentiation  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in regulation of brown fat cell differentiation  
involved_in regulation of brown fat cell differentiation  
involved_in regulation of cytosolic calcium ion concentration  
involved_in regulation of lipid storage PubMed 
involved_in regulation of lipid storage  
involved_in regulation of multicellular organism growth PubMed 
involved_in regulation of respiratory system process PubMed 
involved_in regulation of white fat cell proliferation PubMed 
involved_in sensory perception of pain  
involved_in snRNA processing  
involved_in temperature homeostasis PubMed 
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in intracellular membrane-bounded organelle  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleus PubMed 
located_in nucleus  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
alpha-ketoglutarate-dependent dioxygenase FTO
Names
U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
fat mass and obesity associated
fat mass and obesity-associated protein
m6A(m)-demethylase FTO
mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
mRNA N(6)-methyladenosine demethylase FTO
protein fatso
tRNA N1-methyl adenine demethylase FTO
NP_036066.2
XP_006531099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011936.2NP_036066.2  alpha-ketoglutarate-dependent dioxygenase FTO

    See identical proteins and their annotated locations for NP_036066.2

    Status: VALIDATED

    Source sequence(s)
    BC057008, BY290198, CA321822
    Consensus CDS
    CCDS22521.1
    UniProtKB/Swiss-Prot
    Q3TTZ5, Q6ZPI7, Q8BGW1, Q8BR68, Q8CB66, Q8R250, Q9QZ13
    Related
    ENSMUSP00000068380.8, ENSMUST00000069718.15
    Conserved Domains (2) summary
    pfam12933
    Location:36322
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:326495
    FTO_CTD; FTO C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    92039995..92395061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531036.2XP_006531099.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

    UniProtKB/TrEMBL
    E9Q1E4
    Conserved Domains (1) summary
    pfam12933
    Location:40252
    FTO_NTD; FTO catalytic domain
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