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    Mutyh mutY DNA glycosylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170841, updated on 4-Jan-2025

    Summary

    Official Symbol
    Mutyhprovided by RGD
    Official Full Name
    mutY DNA glycosylaseprovided by RGD
    Primary source
    RGD:620045
    See related
    EnsemblRapid:ENSRNOG00000017887 AllianceGenome:RGD:620045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Myh
    Summary
    Enables DNA N-glycosylase activity. Involved in response to oxidative stress. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; stomach cancer; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 94.0), Spleen (RPKM 54.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mutyh in Genome Data Viewer
    Location:
    5q35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135510666..135522777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130274034..130286149)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135663328..135675348)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163 Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like Neighboring gene ribosomal protein S20, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC156598

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding  
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity  
    enables DNA N-glycosylase activity PubMed 
    enables DNA N-glycosylase activity  
    enables DNA binding  
    NOT enables MutLalpha complex binding  
    NOT enables MutLbeta complex binding  
    enables MutSalpha complex binding  
    enables MutSalpha complex binding  
    NOT enables MutSbeta complex binding  
    enables adenine/guanine mispair binding  
    enables hydrolase activity, acting on glycosyl bonds  
    enables metal ion binding  
    enables oxidized purine DNA binding  
    enables purine-specific mismatch base pair DNA N-glycosylase activity  
    enables purine-specific mismatch base pair DNA N-glycosylase activity  
    enables purine-specific mismatch base pair DNA N-glycosylase activity  
    enables purine-specific mismatch base pair DNA N-glycosylase activity  
    Process Evidence Code Pubs
    involved_in base-excision repair  
    involved_in base-excision repair  
    involved_in mismatch repair  
    involved_in negative regulation of necroptotic process  
    involved_in negative regulation of necroptotic process  
    involved_in response to oxidative stress PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    adenine DNA glycosylase
    Names
    a/G-specific adenine DNA glycosylase
    mutY homolog
    rMYH
    NP_579850.2
    XP_038965128.1
    XP_038965129.1
    XP_038965130.1
    XP_038965131.1
    XP_038965132.1
    XP_038965133.1
    XP_038965135.1
    XP_038965136.1
    XP_063143179.1
    XP_063143180.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133316.2NP_579850.2  adenine DNA glycosylase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8R5G2
      UniProtKB/TrEMBL
      A6JZA6, G3V8C1
      Related
      ENSRNOP00000083752.1, ENSRNOT00000118511.2
      Conserved Domains (1) summary
      COG1194
      Location:63463
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135510666..135522777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109200.2XP_038965128.1  adenine DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63470
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    2. XM_039109202.2XP_038965130.1  adenine DNA glycosylase isoform X2

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63432
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    3. XM_063287109.1XP_063143179.1  adenine DNA glycosylase isoform X3

      UniProtKB/Swiss-Prot
      Q8R5G2
    4. XM_039109208.2XP_038965136.1  adenine DNA glycosylase isoform X8

      Conserved Domains (1) summary
      COG1194
      Location:63282
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    5. XM_039109207.2XP_038965135.1  adenine DNA glycosylase isoform X7

      Conserved Domains (1) summary
      COG1194
      Location:63293
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    6. XM_039109201.2XP_038965129.1  adenine DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63470
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    7. XM_039109203.2XP_038965131.1  adenine DNA glycosylase isoform X4

      Conserved Domains (1) summary
      COG1194
      Location:1364
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    8. XM_039109204.2XP_038965132.1  adenine DNA glycosylase isoform X5

      Conserved Domains (1) summary
      COG1194
      Location:1347
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
    9. XM_063287110.1XP_063143180.1  adenine DNA glycosylase isoform X6

    10. XM_039109205.2XP_038965133.1  adenine DNA glycosylase isoform X5

      Conserved Domains (1) summary
      COG1194
      Location:1347
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    RNA

    1. XR_010066340.1 RNA Sequence

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