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Podxl podocalyxin-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 192181, updated on 4-Jan-2025

Summary

Official Symbol
Podxlprovided by RGD
Official Full Name
podocalyxin-likeprovided by RGD
Primary source
RGD:621878
See related
EnsemblRapid:ENSRNOG00000012495 AllianceGenome:RGD:621878
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PC; PCLP-1; podocalyxin
Summary
Involved in negative regulation of cell adhesion and podocyte development. Located in apical plasma membrane; cell body; and slit diaphragm. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 453.2), Lung (RPKM 207.5) and 7 other tissues See more
Orthologs
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Genomic context

See Podxl in Genome Data Viewer
Location:
4q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (61102434..61149131, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (60135124..60181829, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (58829049..58893353, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102486 Neighboring gene muskelin 1 Neighboring gene peptidylprolyl isomerase D, pseudogene 6 Neighboring gene developmental pluripotency-associated 4, pseudogene 8 Neighboring gene uncharacterized LOC134486572 Neighboring gene uncharacterized LOC134486747 Neighboring gene ribosomal protein L38 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion  
involved_in cell migration  
involved_in cell migration  
involved_in cell migration  
involved_in cell migration  
involved_in epithelial tube formation  
involved_in epithelial tube formation  
involved_in glomerular filtration PubMed 
acts_upstream_of_or_within leukocyte migration  
involved_in negative regulation of cell adhesion PubMed 
involved_in negative regulation of cell adhesion  
involved_in negative regulation of cell-cell adhesion  
involved_in negative regulation of cell-cell adhesion  
involved_in negative regulation of cell-cell adhesion  
involved_in podocyte development PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell-cell adhesion mediated by integrin  
involved_in positive regulation of cell-cell adhesion mediated by integrin  
involved_in positive regulation of cell-cell adhesion mediated by integrin  
involved_in regulation of cell-cell adhesion  
involved_in regulation of microvillus assembly  
involved_in regulation of microvillus assembly  
involved_in regulation of microvillus assembly  
involved_in regulation of synapse assembly  
Items 1 - 20 of 30
Component Evidence Code Pubs
is_active_in apical plasma membrane  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in cell body PubMed 
located_in centriolar satellite  
located_in cytoplasm  
located_in cytoplasm  
located_in extracellular exosome  
located_in filopodium  
located_in filopodium  
located_in filopodium  
is_active_in glutamatergic synapse  
located_in intracellular membrane-bounded organelle  
located_in lamellipodium  
located_in lamellipodium  
located_in lamellipodium  
located_in membrane raft  
located_in microvillus  
is_active_in microvillus membrane  
located_in microvillus membrane  
located_in microvillus membrane  
located_in nucleolus  
located_in plasma membrane  
located_in plasma membrane  
is_active_in presynaptic membrane  
located_in ruffle  
located_in ruffle  
located_in ruffle  
located_in slit diaphragm PubMed 
Items 1 - 20 of 30

General protein information

Preferred Names
podocalyxin
Names
podocalyxin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138848.1 → NP_620203.1  podocalyxin precursor

    See identical proteins and their annotated locations for NP_620203.1

    Status: PROVISIONAL

    Source sequence(s)
    AF109393
    UniProtKB/Swiss-Prot
    Q6IRK7, Q9R068, Q9WTQ2
    UniProtKB/TrEMBL
    A0A8I5YBT0, A6IEJ5
    Related
    ENSRNOP00000075234.2, ENSRNOT00000077406.3
    Conserved Domains (1) summary
    pfam06365
    Location:285 → 484
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    61102434..61149131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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