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RAMAC RNA guanine-7 methyltransferase activating subunit [ Homo sapiens (human) ]

Gene ID: 83640, updated on 4-Jan-2025

Summary

Official Symbol
RAMACprovided by HGNC
Official Full Name
RNA guanine-7 methyltransferase activating subunitprovided by HGNC
Primary source
HGNC:HGNC:31022
See related
Ensembl:ENSG00000169612 MIM:614547; AllianceGenome:HGNC:31022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAM; RAMMET; C15orf18; FAM103A1; HsT19360
Summary
Enables RNA binding activity and enzyme activator activity. Involved in 7-methylguanosine mRNA capping. Located in nucleus. Part of mRNA cap methyltransferase RNMT:RAMAC complex and mRNA capping enzyme complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta (RPKM 19.2), colon (RPKM 16.4) and 25 other tissues See more
Orthologs
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Genomic context

See RAMAC in Genome Data Viewer
Location:
15q25.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (82986210..82991057)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (80850581..80855428)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83654962..83659809)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6756 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:83501038-83502237 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:83518553-83519328 Neighboring gene homer scaffold protein 2 Neighboring gene uncharacterized LOC105370928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:83620722-83621222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:83632148-83632648 Neighboring gene Sharpr-MPRA regulatory region 12194 Neighboring gene chromosome 15 open reading frame 40 Neighboring gene uncharacterized LOC124903542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9968 Neighboring gene BTB domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6758 Neighboring gene fatty acid binding protein 5 pseudogene 8 Neighboring gene microRNA 4515

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC2560, MGC102778

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of mRNA cap methyltransferase RNMT:RAMAC complex PubMed 
part_of mRNA capping enzyme complex  
part_of mRNA capping enzyme complex PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
RNA guanine-N7 methyltransferase activating subunit
Names
RNMT activating mRNA cap methyltransferase subunit
RNMT-activating mini protein
family with sequence similarity 103 member A1
protein FAM103A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031452.4NP_113640.1  RNA guanine-N7 methyltransferase activating subunit

    See identical proteins and their annotated locations for NP_113640.1

    Status: VALIDATED

    Source sequence(s)
    AC022558, BC112329, BQ002618
    Consensus CDS
    CCDS10321.1
    UniProtKB/Swiss-Prot
    Q2M1J8, Q9BTL3
    Related
    ENSP00000307181.3, ENST00000304191.4
    Conserved Domains (1) summary
    pfam15320
    Location:1087
    RAM; mRNA cap methylation, RNMT-activating mini protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    82986210..82991057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    80850581..80855428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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