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Cd8a CD8 subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24930, updated on 4-Jan-2025

Summary

Official Symbol
Cd8aprovided by RGD
Official Full Name
CD8 subunit alphaprovided by RGD
Primary source
RGD:2316
See related
EnsemblRapid:ENSRNOG00000007178 AllianceGenome:RGD:2316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase binding activity. Involved in response to methamphetamine hydrochloride. Located in cell surface. Biomarker of amphetamine abuse and brain infarction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CD8A (CD8 subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 1790.2), Spleen (RPKM 183.6) and 1 other tissue See more
Orthologs
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Genomic context

See Cd8a in Genome Data Viewer
Location:
4q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (104924116..104928353)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103365804..103370041)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99217640..99243352)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486799 Neighboring gene CD8 subunit beta Neighboring gene tubulin, alpha 1B, pseudogene 8 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene transfer RNA serine (anticodon AGA) 32 Neighboring gene ring finger protein 103

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cell surface PubMed 
located_in cell surface  
is_active_in external side of plasma membrane  
located_in external side of plasma membrane  
located_in plasma membrane  
located_in plasma membrane raft  
part_of receptor complex  

General protein information

Preferred Names
T-cell surface glycoprotein CD8 alpha chain
Names
CD8 antigen 32 kDa chain
CD8 antigen, alpha-chain
CD8a molecule
OX-8 membrane antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031538.2NP_113726.1  T-cell surface glycoprotein CD8 alpha chain precursor

    See identical proteins and their annotated locations for NP_113726.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088126
    UniProtKB/Swiss-Prot
    P07725
    UniProtKB/TrEMBL
    A6IA73
    Related
    ENSRNOP00000106503.1, ENSRNOT00000161718.1
    Conserved Domains (2) summary
    smart00410
    Location:32131
    IG_like; Immunoglobulin like
    cl11960
    Location:36137
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    104924116..104928353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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