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Prss2 serine protease 2 [ Mus musculus (house mouse) ]

Gene ID: 22072, updated on 13-Jan-2025

Summary

Official Symbol
Prss2provided by MGI
Official Full Name
serine protease 2provided by MGI
Primary source
MGI:MGI:102759
See related
Ensembl:ENSMUSG00000057163 AllianceGenome:MGI:102759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ta; TRY8; TRYP; Try2; Tesp4
Summary
Enables serine-type endopeptidase activity. Predicted to be involved in several processes, including collagen catabolic process; response to caffeine; and response to nicotine. Located in collagen-containing extracellular matrix. Is expressed in alimentary system; genitourinary system; and spleen. Orthologous to human PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See Prss2 in Genome Data Viewer
Location:
6 B1; 6 19.67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41498710..41502013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41521776..41525079)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene STARR-seq mESC enhancer starr_15699 Neighboring gene serine protease 3 like Neighboring gene STARR-seq mESC enhancer starr_15700 Neighboring gene serine protease 1 (trypsin 1) Neighboring gene STARR-positive B cell enhancer mm9_chr6:41480095-41480396 Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta, D region 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity PubMed 
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in collagen catabolic process  
involved_in collagen catabolic process  
involved_in digestion  
involved_in proteolysis  
involved_in proteolysis  
involved_in proteolysis  
involved_in response to acetaldehyde  
involved_in response to caffeine  
involved_in response to caffeine  
involved_in response to nicotine  
involved_in response to nicotine  
involved_in response to nutrient  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
located_in extracellular region  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
anionic trypsin-2
Names
anionic trypsin II
pretrypsinogen II
protease, serine 2
trypsin 2
trypsinogen 20
NP_033456.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_006980.1 

    Range
    630982..634285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_009430.2NP_033456.1  anionic trypsin-2 precursor

    See identical proteins and their annotated locations for NP_033456.1

    Status: VALIDATED

    Source sequence(s)
    AK003082, BB841364
    Consensus CDS
    CCDS20050.1
    UniProtKB/Swiss-Prot
    P07146
    UniProtKB/TrEMBL
    Q3V2E0, Q792Y6
    Related
    ENSMUSP00000065393.5, ENSMUST00000070380.5
    Conserved Domains (2) summary
    smart00020
    Location:23239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24242
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    41498710..41502013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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