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    Dapk2 death-associated protein kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 13143, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dapk2provided by MGI
    Official Full Name
    death-associated protein kinase 2provided by MGI
    Primary source
    MGI:MGI:1341297
    See related
    Ensembl:ENSMUSG00000032380 AllianceGenome:MGI:1341297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Involved in neutrophil migration. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Is expressed in clavicle; diencephalon lateral wall ventricular layer; mandible; maxilla; and orbito-sphenoid. Orthologous to human DAPK2 (death associated protein kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 10.8), placenta adult (RPKM 9.0) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Dapk2 in Genome Data Viewer
    Location:
    9 C; 9 35.75 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66065364..66179524)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66158226..66272242)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene sorting nexin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene STARR-positive B cell enhancer mm9_chr9:66059936-66060237 Neighboring gene STARR-seq mESC enhancer starr_24478 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66128344-66128644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66129452-66129653 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 39364

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding PubMed 
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables calmodulin binding  
    enables calmodulin binding PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in anoikis  
    involved_in apoptotic process  
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in neutrophil migration PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of eosinophil chemotaxis  
    involved_in positive regulation of neutrophil chemotaxis  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of intrinsic apoptotic signaling pathway  
    involved_in regulation of intrinsic apoptotic signaling pathway PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in autophagosome lumen  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasmic vesicle  
    located_in intracellular membrane-bounded organelle  
    is_active_in nucleus  

    General protein information

    Preferred Names
    death-associated protein kinase 2
    Names
    DAP kinase 2
    DRP-1
    death-associated kinase 2
    NP_001391612.1
    NP_034149.2
    XP_036010490.1
    XP_036010491.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404683.1NP_001391612.1  death-associated protein kinase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124439
      UniProtKB/TrEMBL
      E9JGN0
      Related
      ENSMUSP00000158747.2, ENSMUST00000238682.2
    2. NM_010019.4NP_034149.2  death-associated protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_034149.2

      Status: VALIDATED

      Source sequence(s)
      AC124439
      Consensus CDS
      CCDS23303.1
      UniProtKB/Swiss-Prot
      O88861, Q8VDF3, Q9QYM4
      Related
      ENSMUSP00000034944.3, ENSMUST00000034944.9
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66065364..66179524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154597.1XP_036010490.1  death-associated protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036154598.1XP_036010491.1  death-associated protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004935315.1 RNA Sequence

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