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Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16490, updated on 4-Jan-2025

Summary

Official Symbol
Kcna2provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 2provided by MGI
Primary source
MGI:MGI:96659
See related
Ensembl:ENSMUSG00000040724 AllianceGenome:MGI:96659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mk-2; Kv1.2; Akr6a4; Kca1-2; Gm10672
Summary
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Part of voltage-gated potassium channel complex. Is active in axon initial segment. Is expressed in several structures, including brain; heart ventricle; and hindlimb muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 17.1), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs
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Genomic context

See Kcna2 in Genome Data Viewer
Location:
3 F2.3; 3 46.61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106998203..107022321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107090883..107115005)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 27008 Neighboring gene STARR-seq mESC enhancer starr_08657 Neighboring gene STARR-seq mESC enhancer starr_08658 Neighboring gene STARR-positive B cell enhancer ABC_E826 Neighboring gene STARR-positive B cell enhancer ABC_E7936 Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4573 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106883731-106883985 Neighboring gene STARR-positive B cell enhancer ABC_E7937 Neighboring gene STARR-seq mESC enhancer starr_08660 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10 Neighboring gene chymosin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity  
enables delayed rectifier potassium channel activity  
enables delayed rectifier potassium channel activity  
enables kinesin binding  
enables kinesin binding  
enables outward rectifier potassium channel activity  
enables outward rectifier potassium channel activity  
enables protein binding PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables voltage-gated potassium channel activity PubMed 
enables voltage-gated potassium channel activity PubMed 
enables voltage-gated potassium channel activity  
Process Evidence Code Pubs
involved_in action potential  
involved_in cerebral cortex development  
involved_in corpus callosum development  
involved_in neuronal action potential  
involved_in neuronal action potential  
acts_upstream_of_or_within optic nerve structural organization PubMed 
involved_in potassium ion export across plasma membrane  
involved_in potassium ion export across plasma membrane  
involved_in potassium ion transmembrane transport  
involved_in potassium ion transmembrane transport PubMed 
involved_in potassium ion transmembrane transport  
involved_in protein homooligomerization  
involved_in regulation of circadian sleep/wake cycle, non-REM sleep PubMed 
involved_in regulation of dopamine secretion PubMed 
involved_in regulation of postsynaptic membrane potential  
involved_in regulation of presynaptic membrane potential  
involved_in sensory perception of pain  
involved_in sensory perception of pain  
Items 1 - 20 of 31
Component Evidence Code Pubs
located_in axon PubMed 
is_active_in axon initial segment PubMed 
is_active_in axon terminus  
located_in axon terminus PubMed 
located_in calyx of Held  
is_active_in calyx of Held  
is_active_in dendrite  
located_in dendrite PubMed 
located_in endoplasmic reticulum membrane  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
is_active_in juxtaparanode region of axon  
located_in juxtaparanode region of axon PubMed 
located_in juxtaparanode region of axon  
located_in lamellipodium  
located_in lamellipodium  
located_in lamellipodium membrane  
is_active_in membrane  
located_in neuronal cell body membrane PubMed 
located_in paranodal junction  
located_in perikaryon PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynaptic membrane  
is_active_in postsynaptic membrane  
part_of potassium channel complex  
located_in presynaptic membrane  
is_active_in presynaptic membrane  
part_of voltage-gated potassium channel complex  
part_of voltage-gated potassium channel complex PubMed 
part_of voltage-gated potassium channel complex  
Items 1 - 20 of 31

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 2
Names
MK2
voltage-gated potassium channel subunit Kv1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008417.5NP_032443.3  potassium voltage-gated channel subfamily A member 2

    See identical proteins and their annotated locations for NP_032443.3

    Status: VALIDATED

    Source sequence(s)
    AC121825, AI607461, AK044342
    Consensus CDS
    CCDS17733.1
    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Related
    ENSMUSP00000041702.2, ENSMUST00000038695.6
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106998203..107022321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501055.5XP_006501118.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501118.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  2. XM_036162906.1XP_036018799.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  3. XM_006501049.5XP_006501112.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501112.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Related
    ENSMUSP00000143798.2, ENSMUST00000197470.5
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  4. XM_006501052.5XP_006501115.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501115.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  5. XM_006501051.5XP_006501114.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501114.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  6. XM_006501053.5XP_006501116.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501116.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  7. XM_006501050.4XP_006501113.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501113.1

    UniProtKB/Swiss-Prot
    B2RS05, P15386, P63141, Q02010, Q8C8W4
    Related
    ENSMUSP00000142873.2, ENSMUST00000196403.2
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
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