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    Akap12 A-kinase anchoring protein 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83425, updated on 4-Jan-2025

    Summary

    Official Symbol
    Akap12provided by RGD
    Official Full Name
    A-kinase anchoring protein 12provided by RGD
    Primary source
    RGD:70988
    See related
    EnsemblRapid:ENSRNOG00000019549 AllianceGenome:RGD:70988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AKAP12A; AKAP12B; AKAP12G
    Summary
    Predicted to enable adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of ERK1 and ERK2 cascade. Located in neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 471.5), Lung (RPKM 241.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Akap12 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43135515..43225245)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40730123..40819863)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40816130..40906582)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transcription factor BTF3-like Neighboring gene uncharacterized LOC134484990 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene required for meiotic nuclear division 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenylate cyclase binding  
    enables calmodulin binding  
    enables protein kinase A binding  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in hepatic stellate cell activation PubMed 
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of vascular permeability PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of hepatic stellate cell migration PubMed 
    involved_in positive regulation of oligodendrocyte apoptotic process PubMed 
    involved_in positive regulation of protein kinase A signaling  
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in regulation of protein kinase A signaling  
    involved_in regulation of protein kinase A signaling  
    involved_in regulation of protein kinase C signaling  
    involved_in response to electrical stimulus PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    A-kinase anchor protein 12
    Names
    A kinase (PRKA) anchor protein (gravin) 12
    A kinase (PRKA) anchor protein 12
    AKAP-12
    SSeCKS, Gravin, AKAP250

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033653.1NP_001028825.1  A-kinase anchor protein 12 isoform beta

      See identical proteins and their annotated locations for NP_001028825.1

      Status: VALIDATED

      Source sequence(s)
      AY695057, BG664488
      UniProtKB/TrEMBL
      Q62766
      Related
      ENSRNOP00000070062.1, ENSRNOT00000083702.3
      Conserved Domains (1) summary
      pfam03832
      Location:513540
      WSK; WSK motif
    2. NM_057103.2NP_476444.2  A-kinase anchor protein 12 isoform alpha

      See identical proteins and their annotated locations for NP_476444.2

      Status: VALIDATED

      Source sequence(s)
      AY695056, BG664488
      UniProtKB/Swiss-Prot
      Q5QD49, Q5QD50, Q5QD51, Q9Z1F7
      UniProtKB/TrEMBL
      A6KIK8, Q62766
      Conserved Domains (1) summary
      pfam03832
      Location:593620
      WSK; WSK motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      43135515..43225245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227847.5XP_006227909.1  A-kinase anchor protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006227909.1

      UniProtKB/TrEMBL
      A0A8L2QEC9, A6KIK9, Q62766
      Conserved Domains (1) summary
      pfam03832
      Location:513540
      WSK; WSK motif
    2. XM_006227848.5XP_006227910.1  A-kinase anchor protein 12 isoform X2

      See identical proteins and their annotated locations for XP_006227910.1

      UniProtKB/TrEMBL
      A6KIL0, Q62766
      Related
      ENSRNOP00000026483.8, ENSRNOT00000026482.8
      Conserved Domains (1) summary
      pfam03832
      Location:488515
      WSK; WSK motif
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