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    Myc myelocytomatosis oncogene [ Mus musculus (house mouse) ]

    Gene ID: 17869, updated on 14-Jan-2025

    Summary

    Official Symbol
    Mycprovided by MGI
    Official Full Name
    myelocytomatosis oncogeneprovided by MGI
    Primary source
    MGI:MGI:97250
    See related
    Ensembl:ENSMUSG00000022346 AllianceGenome:MGI:97250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myc2; Nird; Niard; bHLHe39
    Summary
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
    Expression
    Broad expression in ovary adult (RPKM 36.6), thymus adult (RPKM 28.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myc in Genome Data Viewer
    Location:
    15 D1; 15 26.19 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (61857190..61862210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (61985341..61990361)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53889 Neighboring gene STARR-seq mESC enhancer starr_38814 Neighboring gene STARR-seq mESC enhancer starr_38815 Neighboring gene origin of replication upstream of Myc Neighboring gene predicted gene, 18788 Neighboring gene STARR-seq mESC enhancer starr_38818 Neighboring gene STARR-seq mESC enhancer starr_38819 Neighboring gene STARR-seq mESC enhancer starr_38820 Neighboring gene Pvt1 oncogene Neighboring gene STARR-seq mESC enhancer starr_38824 Neighboring gene predicted gene, 53890 Neighboring gene STARR-positive B cell enhancer ABC_E5482 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62001280-62001493 Neighboring gene STARR-positive B cell enhancer ABC_E7373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:62013150-62013450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:62044000-62044201 Neighboring gene macroH2A.3 histone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (25)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables E-box binding  
    enables E-box binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables SCF ubiquitin ligase complex binding  
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables core promoter sequence-specific DNA binding  
    enables double-stranded DNA binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables sequence-specific DNA binding  
    enables transcription coregulator binding  
    enables ubiquitin protein ligase binding PubMed 
    Items 1 - 25 of 26
    Items 1 - 25 of 117
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process PubMed 
    acts_upstream_of_or_within B cell apoptotic process PubMed 
    acts_upstream_of_or_within DNA damage response PubMed 
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA-templated transcription  
    involved_in DNA-templated transcription initiation  
    involved_in ERK1 and ERK2 cascade  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in NK T cell proliferation PubMed 
    acts_upstream_of_or_within Wnt signaling pathway PubMed 
    acts_upstream_of acinar cell proliferation PubMed 
    involved_in amino acid transport  
    involved_in branching involved in ureteric bud morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cellular response to hypoxia  
    acts_upstream_of_or_within cellular response to interferon-alpha PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in cellular response to xenobiotic stimulus  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in chromosome organization  
    involved_in chromosome organization  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound PubMed 
    involved_in glucose metabolic process  
    involved_in inner mitochondrial membrane organization  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage PubMed 
    involved_in lactic acid secretion  
    acts_upstream_of_or_within middle ear morphogenesis PubMed 
    acts_upstream_of_or_within myotube differentiation PubMed 
    involved_in negative regulation of D-glucose import  
    involved_in negative regulation of cell division  
    involved_in negative regulation of cell division  
    involved_in negative regulation of epithelial cell apoptotic process  
    involved_in negative regulation of fibroblast proliferation  
    involved_in negative regulation of gene expression  
    acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of monocyte differentiation  
    involved_in negative regulation of monocyte differentiation  
    acts_upstream_of_or_within negative regulation of protein binding PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription initiation by RNA polymerase II  
    acts_upstream_of_or_within pigmentation PubMed 
    involved_in positive regulation of ATP biosynthetic process  
    acts_upstream_of_or_within positive regulation of B cell apoptotic process PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of acinar cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of catalytic activity PubMed 
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cellular respiration  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in positive regulation of mesenchymal cell proliferation PubMed 
    involved_in positive regulation of metanephric cap mesenchymal cell proliferation PubMed 
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of mitochondrial membrane potential  
    involved_in positive regulation of oxidative phosphorylation  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of telomere maintenance PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II PubMed 
    acts_upstream_of_or_within protein processing PubMed 
    involved_in protein-DNA complex disassembly  
    involved_in pyruvate transport  
    acts_upstream_of rRNA metabolic process  
    involved_in re-entry into mitotic cell cycle  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    involved_in regulation of cell cycle process  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of oxidative phosphorylation  
    involved_in regulation of somatic stem cell population maintenance PubMed 
    involved_in regulation of telomere maintenance  
    involved_in regulation of telomere maintenance  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within response to alkaloid PubMed 
    involved_in response to gamma radiation  
    involved_in response to gamma radiation  
    acts_upstream_of_or_within response to radiation PubMed 
    acts_upstream_of_or_within response to radiation PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis PubMed 
    acts_upstream_of transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    Items 1 - 25 of 117
    Component Evidence Code Pubs
    part_of Myc-Max complex PubMed 
    part_of Myc-Max complex  
    part_of RNA polymerase II transcription repressor complex  
    located_in axon PubMed 
    located_in chromatin  
    located_in euchromatin PubMed 
    located_in nuclear body PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    part_of protein-containing complex  
    located_in spindle PubMed 

    General protein information

    Preferred Names
    myc proto-oncogene protein
    Names
    c-myc proto-oncogene
    transcription factor p64

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177352.1NP_001170823.1  myc proto-oncogene protein isoform b

      See identical proteins and their annotated locations for NP_001170823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (a, also known as c-Myc 1) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The shorter isoform (b) is represented in this RefSeq, and is 15 aa shorter, compared to isoform a. Both variants 1 and 2 can encode isoform b.
      Source sequence(s)
      BB858498, BC138931, BE456204, BE853266
      Consensus CDS
      CCDS49615.1
      UniProtKB/TrEMBL
      A0A991CU09
      Related
      ENSMUSP00000123821.2, ENSMUST00000161976.8
      Conserved Domains (2) summary
      pfam01056
      Location:6345
      Myc_N; Myc amino-terminal region
      cd11458
      Location:351434
      bHLHzip_c-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins
    2. NM_001177353.1NP_001170824.1  myc proto-oncogene protein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This variant encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (c) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The longer isoform (c) is represented in this RefSeq, and is 1 aa shorter, compared to isoform a.
      Source sequence(s)
      AK133952, BE456204, BE853266
      Consensus CDS
      CCDS49614.1
      UniProtKB/TrEMBL
      A0A991CU09
      Related
      ENSMUSP00000130285.2, ENSMUST00000167731.8
      Conserved Domains (3) summary
      cd00083
      Location:366425
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:20359
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:422451
      Myc-LZ; Myc leucine zipper domain
    3. NM_001177354.1NP_001170825.1  myc proto-oncogene protein isoform b

      See identical proteins and their annotated locations for NP_001170825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This variant encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (c) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The shorter isoform (b) is represented in this RefSeq, and is 15 aa shorter, compared to isoform a. Both variants 1 and 2 can encode isoform b.
      Source sequence(s)
      AK133952, BE456204, BE853266
      Consensus CDS
      CCDS49615.1
      UniProtKB/TrEMBL
      A0A991CU09
      Related
      ENSMUSP00000124758.2, ENSMUST00000159327.2
      Conserved Domains (2) summary
      pfam01056
      Location:6345
      Myc_N; Myc amino-terminal region
      cd11458
      Location:351434
      bHLHzip_c-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins
    4. NM_010849.4NP_034979.3  myc proto-oncogene protein isoform a

      See identical proteins and their annotated locations for NP_034979.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (a, also known as c-Myc 1) is derived from a non-AUG (CUG) start codon, while a shorter isoform (b, also known as c-Myc 2) is derived from a downstream AUG start codon. The longer isoform (a) is represented in this RefSeq.
      Source sequence(s)
      BB858498, BC138931, BE456204, BE853266
      Consensus CDS
      CCDS27504.1
      UniProtKB/Swiss-Prot
      A0A087WSQ0, B2RSN1, F6PX41, F8WID3, P01108, P70247, Q3UM70, Q61422
      UniProtKB/TrEMBL
      A0A991B922
      Related
      ENSMUSP00000022971.8, ENSMUST00000022971.8
      Conserved Domains (3) summary
      cd00083
      Location:367426
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:21360
      Myc_N; Myc amino-terminal region
      pfam02344
      Location:423452
      Myc-LZ; Myc leucine zipper domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      61857190..61862210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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