U.S. flag

An official website of the United States government

Trim34a tripartite motif-containing 34A [ Mus musculus (house mouse) ]

Gene ID: 94094, updated on 4-Jan-2025

Summary

Official Symbol
Trim34aprovided by MGI
Official Full Name
tripartite motif-containing 34Aprovided by MGI
Primary source
MGI:MGI:2137359
See related
Ensembl:ENSMUSG00000056144 AllianceGenome:MGI:2137359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim34; Trim34-1
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in central nervous system; testis; and ureter. Orthologous to several human genes including TRIM34 (tripartite motif containing 34). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in mammary gland adult (RPKM 7.3), spleen adult (RPKM 7.0) and 28 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trim34a in Genome Data Viewer
Location:
7 E3; 7 55.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103893657..103911446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104244448..104262244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 6 Neighboring gene STARR-seq mESC enhancer starr_19731 Neighboring gene tripartite motif-containing 6 Neighboring gene predicted gene 8667 Neighboring gene STARR-positive B cell enhancer ABC_E6578 Neighboring gene STARR-seq mESC enhancer starr_19732 Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5 Neighboring gene predicted gene, 57517

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding  
enables transferase activity  
enables ubiquitin protein ligase activity  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in defense response to virus  
involved_in innate immune response  
involved_in protein ubiquitination  
involved_in regulation of gene expression  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in mitochondrion  

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM34A
Names
tripartite motif protein 34
tripartite motif-containing 34
tripartite motif-containing protein 34
tripartite motif-containing protein 34A
NP_001344608.1
NP_001408613.1
NP_109609.2
XP_006508432.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357679.2NP_001344608.1  E3 ubiquitin-protein ligase TRIM34A

    Status: VALIDATED

    Source sequence(s)
    AC123830
    Consensus CDS
    CCDS52342.1
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Related
    ENSMUSP00000055058.6, ENSMUST00000060315.12
    Conserved Domains (4) summary
    TIGR02168
    Location:134241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:1460
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001421684.1NP_001408613.1  E3 ubiquitin-protein ligase TRIM34A

    Status: VALIDATED

    Source sequence(s)
    AC123830
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Related
    ENSMUSP00000102461.2, ENSMUST00000106848.8
  3. NM_030684.4NP_109609.2  E3 ubiquitin-protein ligase TRIM34A

    See identical proteins and their annotated locations for NP_109609.2

    Status: VALIDATED

    Source sequence(s)
    AC123830
    Consensus CDS
    CCDS52342.1
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Related
    ENSMUSP00000102462.3, ENSMUST00000106849.9
    Conserved Domains (4) summary
    TIGR02168
    Location:134241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:1460
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_185321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123830

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103893657..103911446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508369.4XP_006508432.1  E3 ubiquitin-protein ligase TRIM34A isoform X1

    See identical proteins and their annotated locations for XP_006508432.1

    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Conserved Domains (4) summary
    TIGR02168
    Location:134241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:1460
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_003946603.2 RNA Sequence

  2. XR_004934226.1 RNA Sequence

External link. Please review our privacy policy.