Protein interactions
Protein |
Gene |
Interaction |
Pubs |
nucleocapsid
|
gag
|
Expression of human topoisomerase I in African green monkey cells enhances the infectivity of HIV-1 in these cells |
PubMed
|
|
gag
|
Topoisomerase I activity has been detected in HIV particles and HIV-1 nucleocapsid has been shown to interact with and enhance the activity of cellular topoisomerase I, thereby enhancing HIV-1 reverse transcription |
PubMed
|
reverse transcriptase
|
gag-pol
|
Topoisomerase I and adenosine triphosphate (ATP) enhance cDNA synthesis by HIV-1 reverse transcriptase, and Topoisomerase I mutants R488A and K532A, lacking enzymatic activity, attenuate the efficiency of cDNA synthesis |
PubMed
|
|
gag-pol
|
Topoisomerase I (topo I) enhances HIV-1 reverse transcriptase activity in vitro and this effect can be inhibited by the topo I-specific inhibitor camptothecin |
PubMed
|
Go to the HIV-1, Human Interaction Database