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NPM3 nucleophosmin/nucleoplasmin 3 [ Homo sapiens (human) ]

Gene ID: 10360, updated on 5-Jan-2025

Summary

Official Symbol
NPM3provided by HGNC
Official Full Name
nucleophosmin/nucleoplasmin 3provided by HGNC
Primary source
HGNC:HGNC:7931
See related
Ensembl:ENSG00000107833 MIM:606456; AllianceGenome:HGNC:7931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PORMIN; TMEM123
Summary
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in testis (RPKM 11.1), appendix (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See NPM3 in Genome Data Viewer
Location:
10q24.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101781325..101783446, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102664820..102666941, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103541082..103543203, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103517739-103518240 Neighboring gene VISTA enhancer hs511 Neighboring gene uncharacterized LOC105378457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103529890-103530667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534038-103534776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534777-103535515 Neighboring gene FGF8 5' regulatory region Neighboring gene fibroblast growth factor 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene O-GlcNAcase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene potassium voltage-gated channel interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with nucleophosmin/nucleoplasmin 3 (NPM3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding PubMed 
enables RNA binding  
enables chromatin binding  
enables histone binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling  
involved_in rRNA processing  
involved_in rRNA transcription  
Component Evidence Code Pubs
located_in actin cytoskeleton  
is_active_in cytoplasm  
located_in cytosol  
is_active_in nucleolus  
located_in nucleolus  
is_active_in nucleoplasm  

General protein information

Preferred Names
nucleoplasmin-3
Names
nucleophosmin/nucleoplasmin family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006993.3NP_008924.1  nucleoplasmin-3

    See identical proteins and their annotated locations for NP_008924.1

    Status: VALIDATED

    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS7519.1
    UniProtKB/Swiss-Prot
    O75607, Q9UNY6
    Related
    ENSP00000359128.5, ENST00000370110.6
    Conserved Domains (1) summary
    pfam03066
    Location:38137
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101781325..101783446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102664820..102666941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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