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RECK reversion inducing cysteine rich protein with kazal motifs [ Homo sapiens (human) ]

Gene ID: 8434, updated on 4-Jan-2025

Summary

Official Symbol
RECKprovided by HGNC
Official Full Name
reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
Primary source
HGNC:HGNC:11345
See related
Ensembl:ENSG00000122707 MIM:605227; AllianceGenome:HGNC:11345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST15
Summary
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
Orthologs
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Genomic context

See RECK in Genome Data Viewer
Location:
9p13.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36036913..36124455)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36058906..36146459)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36036910..36124452)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36102296-36102796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28346 Neighboring gene GLI pathogenesis related 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36161748-36162328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36162329-36162909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36166491-36166991 Neighboring gene calicin

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding  
enables coreceptor activity  
enables endopeptidase inhibitor activity  
enables endopeptidase inhibitor activity PubMed 
enables metalloendopeptidase inhibitor activity PubMed 
enables protein binding PubMed 
enables serine-type endopeptidase inhibitor activity  
Process Evidence Code Pubs
involved_in blood vessel maturation  
involved_in canonical Wnt signaling pathway  
involved_in embryo implantation  
involved_in embryonic forelimb morphogenesis  
involved_in extracellular matrix organization  
involved_in negative regulation of cell migration PubMed 
involved_in negative regulation of metalloendopeptidase activity PubMed 
involved_in negative regulation of metalloendopeptidase activity  
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in regulation of angiogenesis  
involved_in regulation of canonical Wnt signaling pathway  
involved_in regulation of establishment of blood-brain barrier  
involved_in regulation of extracellular matrix organization PubMed 
involved_in sprouting angiogenesis  
Component Evidence Code Pubs
part_of Wnt signalosome  
located_in extracellular region  
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in side of membrane  

General protein information

Preferred Names
reversion-inducing cysteine-rich protein with Kazal motifs
Names
membrane-anchored glycoprotein (metastasis and invasion)
suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)
suppressor of tumorigenicity 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316345.2NP_001303274.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC050306
    UniProtKB/TrEMBL
    A8K9D8
    Conserved Domains (2) summary
    pfam14828
    Location:674739
    Amnionless
    cl28910
    Location:505571
    MFS; Major Facilitator Superfamily
  2. NM_001316346.2NP_001303275.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, AL138834, BC060806, BX393623, CA431378
    UniProtKB/TrEMBL
    Q6P9E2
  3. NM_001316347.2NP_001303276.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378, JQ756320
    UniProtKB/TrEMBL
    Q6P9E2
  4. NM_001316348.2NP_001303277.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK292653, BC060806, CA431378
    UniProtKB/TrEMBL
    Q6P9E2
    Related
    ENST00000479053.1
  5. NM_021111.3NP_066934.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

    See identical proteins and their annotated locations for NP_066934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK292653, BC050306, D50406
    Consensus CDS
    CCDS6597.1
    UniProtKB/Swiss-Prot
    B2RNS1, O95980, Q5W0K6, Q8WX37
    UniProtKB/TrEMBL
    A8K9D8
    Related
    ENSP00000367202.3, ENST00000377966.4
    Conserved Domains (2) summary
    pfam03137
    Location:633658
    OATP; Organic Anion Transporter Polypeptide (OATP) family
    pfam14828
    Location:802886
    Amnionless; Amnionless

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    36036913..36124455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015207.2XP_016870696.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

    UniProtKB/TrEMBL
    A8K9D8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    36058906..36146459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363985.1XP_054219960.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

    UniProtKB/TrEMBL
    A8K9D8
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