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HIPK1 homeodomain interacting protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 204851, updated on 4-Jan-2025

Summary

Official Symbol
HIPK1provided by HGNC
Official Full Name
homeodomain interacting protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:19006
See related
Ensembl:ENSG00000163349 MIM:608003; AllianceGenome:HGNC:19006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Myak; Nbak2
Summary
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 35.1), testis (RPKM 21.2) and 25 other tissues See more
Orthologs
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Genomic context

See HIPK1 in Genome Data Viewer
Location:
1p13.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (113929324..113977869)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (113940985..113989530)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114471946..114520491)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene AP4B1 antisense RNA 1 Neighboring gene BCL2 like 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1541 Neighboring gene adaptor related protein complex 4 subunit beta 1 Neighboring gene GATA motif-containing MPRA enhancer 196 Neighboring gene DNA cross-link repair 1B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1218 Neighboring gene HIPK1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114480377-114480904 Neighboring gene MPRA-validated peak375 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:114519457-114520034 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:114521340-114522173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:114523841-114524673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:114525929-114526892 Neighboring gene olfactomedin like 3 Neighboring gene ribosomal protein L13a pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • KIAA0630, MGC26642, MGC33446, MGC33548

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein tyrosine kinase activity  
enables ribosomal protein S6 kinase activity  
Process Evidence Code Pubs
involved_in adherens junction assembly  
involved_in anterior/posterior pattern specification  
involved_in cell population proliferation  
involved_in chromatin remodeling  
involved_in definitive hemopoiesis PubMed 
involved_in embryonic camera-type eye morphogenesis  
involved_in embryonic retina morphogenesis in camera-type eye  
involved_in endothelial cell apoptotic process PubMed 
involved_in extrinsic apoptotic signaling pathway PubMed 
involved_in eye development PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
involved_in iris morphogenesis  
involved_in lens induction in camera-type eye  
involved_in neuron differentiation  
involved_in positive regulation of angiogenesis PubMed 
involved_in positive regulation of cell population proliferation  
involved_in protein phosphorylation PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway PubMed 
involved_in retina layer formation  
involved_in smoothened signaling pathway  
Component Evidence Code Pubs
is_active_in PML body  
located_in centrosome  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in nuclear speck  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
homeodomain-interacting protein kinase 1
Names
homeodomain interacting protein kinase 1-like protein
nuclear body associated kinase 2b
nuclear body-associated kinase 2
NP_001356735.1
NP_001356736.1
NP_001397776.1
NP_689909.2
NP_852003.1
NP_938009.1
NP_938010.1
XP_005270667.2
XP_005270668.2
XP_006710506.2
XP_011539279.2
XP_047305075.1
XP_047305084.1
XP_047305085.1
XP_047305086.1
XP_047305090.1
XP_047305095.1
XP_054191016.1
XP_054191017.1
XP_054191018.1
XP_054191019.1
XP_054191020.1
XP_054191021.1
XP_054191022.1
XP_054191023.1
XP_054191024.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369806.1NP_001356735.1  homeodomain-interacting protein kinase 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    Consensus CDS
    CCDS867.1
    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Related
    ENSP00000358571.1, ENST00000369558.5
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  2. NM_001369807.1NP_001356736.1  homeodomain-interacting protein kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  3. NM_001410847.1NP_001397776.1  homeodomain-interacting protein kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137856, AL731797
    Consensus CDS
    CCDS91025.1
    UniProtKB/TrEMBL
    A6NDY4, J3KP92, Q5SQL3
    Related
    ENSP00000358574.4, ENST00000369561.8
  4. NM_152696.4NP_689909.2  homeodomain-interacting protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_689909.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 3' UTR and coding region, compared to variant 1. This results in a protein (isoform 2) which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB089957, AL137856, BC033012
    Consensus CDS
    CCDS868.1
    UniProtKB/TrEMBL
    B3KV38
    Related
    ENSP00000358572.4, ENST00000369559.8
    Conserved Domains (2) summary
    smart00220
    Location:190518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  5. NM_181358.3NP_852003.1  homeodomain-interacting protein kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_852003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA995033, AK302726, AL731797, BC033012, BC036057
    Consensus CDS
    CCDS869.1
    UniProtKB/Swiss-Prot
    Q86Z02
    UniProtKB/TrEMBL
    B4DZ33
    Related
    ENSP00000358566.1, ENST00000369553.5
    Conserved Domains (2) summary
    COG0515
    Location:51225
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:6134
    PKc_like; Protein Kinases, catalytic domain
  6. NM_198268.3NP_938009.1  homeodomain-interacting protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_938009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA995033, AK302726, AL137856, AL731797, BC033012
    Consensus CDS
    CCDS867.1
    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Related
    ENSP00000407442.3, ENST00000426820.7
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  7. NM_198269.3NP_938010.1  homeodomain-interacting protein kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_938010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks one 5' coding exon, compared to variant 1. These differences result in the use of a downstream translation initiation site and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA995033, AK302726, AL731797, BC028408
    Consensus CDS
    CCDS41370.1
    Related
    ENSP00000340956.4, ENST00000340480.8
    Conserved Domains (2) summary
    COG0515
    Location:71245
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    113929324..113977869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270611.6XP_005270668.2  homeodomain-interacting protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  2. XM_005270610.6XP_005270667.2  homeodomain-interacting protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  3. XM_047449119.1XP_047305075.1  homeodomain-interacting protein kinase 1 isoform X3

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  4. XM_006710443.5XP_006710506.2  homeodomain-interacting protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A6NDY4, J3KP92, Q5SQL3
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  5. XM_047449130.1XP_047305086.1  homeodomain-interacting protein kinase 1 isoform X8

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  6. XM_047449128.1XP_047305084.1  homeodomain-interacting protein kinase 1 isoform X5

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  7. XM_011540977.4XP_011539279.2  homeodomain-interacting protein kinase 1 isoform X6

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
    Conserved Domains (1) summary
    cl21453
    Location:174488
    PKc_like; Protein Kinases, catalytic domain
  8. XM_047449129.1XP_047305085.1  homeodomain-interacting protein kinase 1 isoform X7

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  9. XM_047449139.1XP_047305095.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  10. XM_047449134.1XP_047305090.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    113940985..113989530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335042.1XP_054191017.1  homeodomain-interacting protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  2. XM_054335041.1XP_054191016.1  homeodomain-interacting protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  3. XM_054335043.1XP_054191018.1  homeodomain-interacting protein kinase 1 isoform X3

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  4. XM_054335044.1XP_054191019.1  homeodomain-interacting protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A6NDY4, J3KP92, Q5SQL3
  5. XM_054335048.1XP_054191023.1  homeodomain-interacting protein kinase 1 isoform X8

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  6. XM_054335045.1XP_054191020.1  homeodomain-interacting protein kinase 1 isoform X5

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  7. XM_054335046.1XP_054191021.1  homeodomain-interacting protein kinase 1 isoform X6

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  8. XM_054335047.1XP_054191022.1  homeodomain-interacting protein kinase 1 isoform X7

    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
  9. XM_054335049.1XP_054191024.1  homeodomain-interacting protein kinase 1 isoform X9

    UniProtKB/Swiss-Prot
    A6NJ34, O75125, Q5SQL2, Q5SQL4, Q5SQL5, Q86Z02, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1
    UniProtKB/TrEMBL
    A6NDY4, Q5SQL3
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