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Slc22a3 solute carrier family 22 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29504, updated on 4-Jan-2025

Summary

Official Symbol
Slc22a3provided by RGD
Official Full Name
solute carrier family 22 member 3provided by RGD
Primary source
RGD:3701
See related
EnsemblRapid:ENSRNOG00000022946 AllianceGenome:RGD:3701
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EMT; OCT3
Summary
Enables several functions, including dopamine:sodium symporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including histamine transport; monoamine transport; and spermidine transport. Located in apical plasma membrane; endomembrane system; and mitochondrial membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 72.3), Heart (RPKM 35.3) and 8 other tissues See more
Orthologs
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Genomic context

See Slc22a3 in Genome Data Viewer
Location:
1q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50783218..50872358)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48235476..48324617)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48433079..48521261)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 10 Neighboring gene uncharacterized LOC102553224 Neighboring gene plasminogen Neighboring gene deoxyuridine triphosphatase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dopamine:sodium symporter activity PubMed 
enables monoamine transmembrane transporter activity PubMed 
enables monoamine transmembrane transporter activity  
enables neurotransmitter transmembrane transporter activity PubMed 
enables neurotransmitter transmembrane transporter activity  
enables organic anion transmembrane transporter activity PubMed 
enables organic cation transmembrane transporter activity  
enables organic cation transmembrane transporter activity PubMed 
enables organic cation transmembrane transporter activity  
enables protein binding PubMed 
enables quaternary ammonium group transmembrane transporter activity PubMed 
enables quaternary ammonium group transmembrane transporter activity  
enables spermidine transmembrane transporter activity PubMed 
enables toxin transmembrane transporter activity PubMed 
enables toxin transmembrane transporter activity  
enables transmembrane transporter activity  
Items 1 - 25 of 38
Process Evidence Code Pubs
involved_in cellular detoxification  
involved_in dopamine transport PubMed 
involved_in dopamine transport  
involved_in dopamine uptake  
involved_in epinephrine transport PubMed 
involved_in epinephrine transport  
involved_in epinephrine uptake  
acts_upstream_of_or_within establishment of localization in cell  
involved_in histamine transport PubMed 
acts_upstream_of_or_within histamine transport  
involved_in histamine transport  
acts_upstream_of_or_within histamine uptake  
involved_in histamine uptake  
acts_upstream_of_or_within monoamine transport  
involved_in monoamine transport  
involved_in monoatomic ion transport  
acts_upstream_of_or_within monocarboxylic acid transport  
acts_upstream_of_or_within neurotransmitter transport  
involved_in neurotransmitter transport  
involved_in norepinephrine transport PubMed 
involved_in norepinephrine transport  
involved_in norepinephrine uptake  
involved_in organic anion transport PubMed 
involved_in organic cation transport  
involved_in organic cation transport PubMed 
acts_upstream_of_or_within organic cation transport  
involved_in organic cation transport  
acts_upstream_of_or_within organic hydroxy compound transport  
involved_in quaternary ammonium group transport PubMed 
acts_upstream_of_or_within quaternary ammonium group transport  
involved_in quaternary ammonium group transport  
acts_upstream_of_or_within regulation of appetite  
involved_in serotonin transport PubMed 
involved_in serotonin transport  
involved_in serotonin uptake  
involved_in spermidine transmembrane transport  
involved_in spermidine transport PubMed 
involved_in xenobiotic transport  
Items 1 - 25 of 38
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in endomembrane system PubMed 
located_in endomembrane system  
located_in mitochondrial membrane PubMed 
located_in mitochondrial membrane  
located_in neuronal cell body  
located_in nuclear outer membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in presynapse  

General protein information

Preferred Names
solute carrier family 22 member 3
Names
extraneuronal monoamine transporter
organic cation transporter 3
solute carrier family 22 (extraneuronal monoamine transporter), member 3
solute carrier family 22 (organic cation transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019230.1NP_062103.1  solute carrier family 22 member 3

    See identical proteins and their annotated locations for NP_062103.1

    Status: PROVISIONAL

    Source sequence(s)
    AF055286
    UniProtKB/Swiss-Prot
    O88446
    UniProtKB/TrEMBL
    A6KJX6
    Related
    ENSRNOP00000029748.2, ENSRNOT00000037369.4
    Conserved Domains (2) summary
    cd06174
    Location:145513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12523
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    50783218..50872358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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