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Eme1 essential meiotic structure-specific endonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 268465, updated on 4-Jan-2025

Summary

Official Symbol
Eme1provided by MGI
Official Full Name
essential meiotic structure-specific endonuclease 1provided by MGI
Primary source
MGI:MGI:3576783
See related
Ensembl:ENSMUSG00000039055 AllianceGenome:MGI:3576783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6820428D13
Summary
Predicted to enable DNA binding activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to act upstream of or within response to intra-S DNA damage checkpoint signaling. Located in heterochromatin. Is expressed in several structures, including adrenal medulla; cerebral cortex; respiratory system; sensory organ; and skeleton. Orthologous to human EME1 (essential meiotic structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E11.5 (RPKM 17.9), cortex adult (RPKM 15.1) and 26 other tissues See more
Orthologs
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Genomic context

See Eme1 in Genome Data Viewer
Location:
11 D; 11 58.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94535798..94544611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94644972..94653836, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene STARR-seq mESC enhancer starr_30470 Neighboring gene chondroadherin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94452878-94453079 Neighboring gene STARR-seq mESC enhancer starr_30472 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94490883-94491183 Neighboring gene leucine rich repeat containing 59 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase II Neighboring gene STARR-positive B cell enhancer ABC_E8444 Neighboring gene predicted gene 11541

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC106543

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables DNA binding  
contributes_to crossover junction DNA endonuclease activity  
enables endonuclease activity  
enables metal ion binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in DNA recombination  
involved_in double-strand break repair  
involved_in double-strand break repair  
involved_in mitotic intra-S DNA damage checkpoint signaling  
involved_in replication fork processing  
involved_in replication fork processing  
involved_in resolution of meiotic recombination intermediates  
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling  
Component Evidence Code Pubs
part_of Holliday junction resolvase complex  
part_of Holliday junction resolvase complex  
located_in chromatin PubMed 
part_of endodeoxyribonuclease complex  
located_in heterochromatin PubMed 
located_in nuclear replication fork PubMed 
located_in nucleolus  

General protein information

Preferred Names
crossover junction endonuclease EME1
Names
essential meiotic endonuclease 1 homolog 1
NP_001366617.1
NP_808420.1
XP_011247347.1
XP_030101897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379688.1NP_001366617.1  crossover junction endonuclease EME1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645764
    Conserved Domains (1) summary
    cd20081
    Location:243471
    XPF_nuclease_EME1; XPF-like nuclease domain of crossover junction endonuclease EME1
  2. NM_177752.5NP_808420.1  crossover junction endonuclease EME1 isoform 2

    See identical proteins and their annotated locations for NP_808420.1

    Status: VALIDATED

    Source sequence(s)
    AL645764
    Consensus CDS
    CCDS25262.1
    UniProtKB/Swiss-Prot
    Q8BJW7
    Related
    ENSMUSP00000036361.5, ENSMUST00000039949.5
    Conserved Domains (2) summary
    pfam02732
    Location:271439
    ERCC4; ERCC4 domain
    pfam07304
    Location:56115
    SRA1; Steroid receptor RNA activator (SRA1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94535798..94544611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246037.2XP_030101897.1  crossover junction endonuclease EME1 isoform X2

  2. XM_011249045.1XP_011247347.1  crossover junction endonuclease EME1 isoform X1

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