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Impact impact, RWD domain protein [ Mus musculus (house mouse) ]

Gene ID: 16210, updated on 4-Jan-2025

Summary

Official Symbol
Impactprovided by MGI
Official Full Name
impact, RWD domain proteinprovided by MGI
Primary source
MGI:MGI:1098233
See related
Ensembl:ENSMUSG00000024423 AllianceGenome:MGI:1098233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430016J11Rik
Summary
Enables actin binding activity; protein sequestering activity; and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Located in cytoplasm. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
Orthologs
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Genomic context

See Impact in Genome Data Viewer
Location:
18 A1; 18 6.87 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13087747..13126007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12954690..12992950)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene histamine receptor H4 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  

General protein information

Preferred Names
protein IMPACT
Names
imprinted and ancient gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357396.1NP_001344325.1  protein IMPACT isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131672, BM899561
    Conserved Domains (2) summary
    smart00591
    Location:197
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164270
    UPF0029; Uncharacterized protein family UPF0029
  2. NM_008378.3NP_032404.1  protein IMPACT isoform 1

    See identical proteins and their annotated locations for NP_032404.1

    Status: VALIDATED

    Source sequence(s)
    AC131672, AK138136, BM899561, CJ056911
    Consensus CDS
    CCDS29068.1
    UniProtKB/Swiss-Prot
    O55091, Q3UUR6, Q9EQH0
    Related
    ENSMUSP00000025290.6, ENSMUST00000025290.7
    Conserved Domains (2) summary
    smart00591
    Location:15115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:181288
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    13087747..13126007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246850.3XP_011245152.1  protein IMPACT isoform X1

    See identical proteins and their annotated locations for XP_011245152.1

    Conserved Domains (2) summary
    smart00591
    Location:197
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164270
    UPF0029; Uncharacterized protein family UPF0029

RNA

  1. XR_001782344.3 RNA Sequence

  2. XR_004939837.1 RNA Sequence

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