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Tsc22d4 TSC22 domain family, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684980, updated on 4-Jan-2025

Summary

Symbol
Tsc22d4provided by RGD
Full Name
TSC22 domain family, member 4provided by RGD
Primary source
RGD:1584380
See related
EnsemblRapid:ENSRNOG00000050805 AllianceGenome:RGD:1584380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tilz2; Spacdr; thg-1pit
Summary
Predicted to be involved in several processes, including glucose homeostasis; negative regulation of transcription by RNA polymerase II; and neuron projection extension. Predicted to be located in several cellular components, including dendrite; nucleus; and synapse. Orthologous to human TSC22D4 (TSC22 domain family member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 264.0), Thymus (RPKM 115.8) and 8 other tissues See more
Orthologs
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Genomic context

See Tsc22d4 in Genome Data Viewer
Location:
12q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24575948..24588806, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18939150..18952008, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22008956..22021814, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene methylphosphate capping enzyme Neighboring gene protein phosphatase 1, regulatory subunit 35 Neighboring gene sperm acrosome developmental regulator Neighboring gene uncharacterized LOC134481171 Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 Neighboring gene enoyl CoA hydratase domain containing 2, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC125073

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in glucose homeostasis  
involved_in glucose homeostasis  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in neuron cellular homeostasis  
involved_in neuron cellular homeostasis  
involved_in neuron projection extension  
involved_in neuron projection extension  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to osmotic stress  
acts_upstream_of_or_within response to osmotic stress  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
located_in dendrite  
located_in dendrite  
located_in nucleus  
located_in nucleus  
located_in synapse  
located_in synapse  

General protein information

Preferred Names
TSC22 domain family protein 4
Names
TSC22-related-inducible leucine zipper protein 2
sperm acrosome developmental regulator
uncharacterized protein C7orf61 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044284.3 → NP_001037749.1  TSC22 domain family protein 4

    See identical proteins and their annotated locations for NP_001037749.1

    Status: VALIDATED

    Source sequence(s)
    FM034641, FM049873, JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3B8N7
    Related
    ENSRNOP00000033658.4, ENSRNOT00000039280.7
    Conserved Domains (1) summary
    cd21941
    Location:308 → 382
    ZIP_TSC22D4; leucine zipper domain found in TSC22 domain family protein 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24575948..24588806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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