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Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 [ Mus musculus (house mouse) ]

Gene ID: 13085, updated on 4-Jan-2025

Summary

Official Symbol
Cyp2a12provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily a, polypeptide 12provided by MGI
Primary source
MGI:MGI:105055
See related
Ensembl:ENSMUSG00000060407 AllianceGenome:MGI:105055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in coumarin metabolic process; epoxygenase P450 pathway; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward liver adult (RPKM 255.5) See more
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Genomic context

See Cyp2a12 in Genome Data Viewer
Location:
7 A3; 7 15.77 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26728515..26736243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27029090..27036818)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57503 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 22 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18341 Neighboring gene STARR-seq mESC enhancer starr_18342 Neighboring gene predicted gene, 51444 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene predicted gene, 29754

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in coumarin metabolic process  
involved_in epoxygenase P450 pathway  
involved_in xenobiotic metabolic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  

General protein information

Preferred Names
cytochrome P450 2A12
Names
CYPIIA12
cytochrome P450, 2a12
steroid hormones 7-alpha-hydroxylase
testosterone 7-alpha-hydroxylase
NP_598418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133657.1NP_598418.1  cytochrome P450 2A12

    See identical proteins and their annotated locations for NP_598418.1

    Status: VALIDATED

    Source sequence(s)
    BC018356
    Consensus CDS
    CCDS21009.1
    UniProtKB/Swiss-Prot
    P56593, Q8VCW9
    Related
    ENSMUSP00000074990.6, ENSMUST00000075552.7
    Conserved Domains (1) summary
    pfam00067
    Location:33489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26728515..26736243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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