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Nek1 NIMA (never in mitosis gene a)-related expressed kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18004, updated on 4-Jan-2025

Summary

Official Symbol
Nek1provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 1provided by MGI
Primary source
MGI:MGI:97303
See related
Ensembl:ENSMUSG00000031644 AllianceGenome:MGI:97303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kat; D8Ertd790e
Summary
Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including DNA damage response; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including ganglia; gut; hemolymphoid system gland; metanephros; and reproductive system. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome II; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 28 other tissues See more
Orthologs
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Genomic context

See Nek1 in Genome Data Viewer
Location:
8 B3.1; 8 30.91 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61446184..61584383)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (60993157..61131349)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:63369016-63369317 Neighboring gene histone PARylation factor 1 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene predicted gene, 18394 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene STARR-positive B cell enhancer ABC_E11383 Neighboring gene STARR-seq mESC enhancer starr_21581 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene predicted gene, 40499

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8) 
  • Spontaneous (2)  1 citation

Interactions

General gene information

Clone Names

  • MGC189817

Gene Ontology Provided by MGI

Items 1 - 25 of 28
Function Evidence Code Pubs
enables 14-3-3 protein binding PubMed 
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables kinase activity  
enables metal ion binding  
enables protein kinase activity  
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein tyrosine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 28
Component Evidence Code Pubs
located_in centriolar satellite  
located_in centrosome PubMed 
located_in centrosome  
located_in cytoplasm PubMed 
located_in cytosol  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus PubMed 
located_in pericentriolar material  

General protein information

Preferred Names
serine/threonine-protein kinase Nek1
Names
NIMA-related kinase 1
NY-REN-55 antigen
Nek1 serine/threonine- and tyrosine-specific protein kinase
kidney, anemia and testis
never in mitosis A-related kinase 1
nimA-related protein kinase 1
NP_001280566.1
NP_001280567.1
NP_001280568.1
NP_001401155.1
NP_001401156.1
NP_001401157.1
NP_001401158.1
NP_001401159.1
NP_780298.2
XP_030099200.1
XP_036009687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293637.1NP_001280566.1  serine/threonine-protein kinase Nek1 isoform 1

    See identical proteins and their annotated locations for NP_001280566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159302, AK135564, AY850065, BC070443, CX237035
    Consensus CDS
    CCDS85541.1
    UniProtKB/TrEMBL
    B2RXX0, Q69Z74
    Related
    ENSMUSP00000147809.2, ENSMUST00000211672.2
    Conserved Domains (2) summary
    smart00220
    Location:4258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08218
    Location:3258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
  2. NM_001293638.1NP_001280567.1  serine/threonine-protein kinase Nek1 isoform 2

    See identical proteins and their annotated locations for NP_001280567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC159302, AK135564, AY850065, BC070443, CX237035
    Consensus CDS
    CCDS80879.1
    UniProtKB/TrEMBL
    B7ZWK0, Q69Z74
    Related
    ENSMUSP00000113932.2, ENSMUST00000120689.8
    Conserved Domains (2) summary
    smart00220
    Location:4258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08218
    Location:3258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
  3. NM_001293639.1NP_001280568.1  serine/threonine-protein kinase Nek1 isoform 4

    See identical proteins and their annotated locations for NP_001280568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded protein (isoform 4) is shorter, compared to isoform 1.
    Source sequence(s)
    AK135564, AY850065, BC070443, CX237035
    Consensus CDS
    CCDS85542.1
    UniProtKB/TrEMBL
    B2RXQ4, Q69Z74
    Related
    ENSMUSP00000147258.2, ENSMUST00000211256.2
    Conserved Domains (2) summary
    smart00220
    Location:4258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08218
    Location:3258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
  4. NM_001414226.1NP_001401155.1  serine/threonine-protein kinase Nek1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134339, AC159302
    UniProtKB/TrEMBL
    Q69Z74
  5. NM_001414227.1NP_001401156.1  serine/threonine-protein kinase Nek1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC134339, AC159302
    UniProtKB/TrEMBL
    Q69Z74
  6. NM_001414228.1NP_001401157.1  serine/threonine-protein kinase Nek1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC134339, AC159302
    UniProtKB/TrEMBL
    Q69Z74
  7. NM_001414229.1NP_001401158.1  serine/threonine-protein kinase Nek1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC134339, AC159302
    UniProtKB/TrEMBL
    Q69Z74
  8. NM_001414230.1NP_001401159.1  serine/threonine-protein kinase Nek1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC134339, AC159302
  9. NM_175089.4NP_780298.2  serine/threonine-protein kinase Nek1 isoform 3

    See identical proteins and their annotated locations for NP_780298.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK135564, AY850065, BC070443, CX237035
    Consensus CDS
    CCDS40347.1
    UniProtKB/Swiss-Prot
    P51954
    UniProtKB/TrEMBL
    Q69Z74
    Related
    ENSMUSP00000034065.8, ENSMUST00000034065.14
    Conserved Domains (2) summary
    smart00220
    Location:4258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08218
    Location:3258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    61446184..61584383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153794.1XP_036009687.1  serine/threonine-protein kinase Nek1 isoform X7

    Conserved Domains (1) summary
    cd08218
    Location:3258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
  2. XM_030243340.2XP_030099200.1  serine/threonine-protein kinase Nek1 isoform X5

    UniProtKB/TrEMBL
    Q69Z74
    Conserved Domains (1) summary
    cl21453
    Location:1179
    PKc_like; Protein Kinases, catalytic domain
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