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    Kat6a lysine acetyltransferase 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306571, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kat6aprovided by RGD
    Official Full Name
    lysine acetyltransferase 6Aprovided by RGD
    Primary source
    RGD:1304892
    See related
    EnsemblRapid:ENSRNOG00000025174 AllianceGenome:RGD:1304892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Moz; Myst3; Znf220; Runxbp2
    Summary
    Predicted to enable several functions, including histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in positive regulation of gene expression. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Arboleda-Tham syndrome and acute myeloid leukemia. Orthologous to human KAT6A (lysine acetyltransferase 6A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 165.5), Lung (RPKM 149.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Kat6a in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75787411..75868584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69084914..69165923, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (73942669..74020750, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ankyrin 1 Neighboring gene uncharacterized LOC120097525 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1-like Neighboring gene uncharacterized LOC134482522 Neighboring gene uncharacterized LOC120097527 Neighboring gene uncharacterized LOC120097529 Neighboring gene K(lysine) acetyltransferase 6A like Neighboring gene uncharacterized LOC134482521 Neighboring gene adaptor related protein complex 3 subunit mu 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 42
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables chromatin binding  
    enables chromatin binding  
    enables histone H2AK5 acetyltransferase activity  
    enables histone H2AK9 acetyltransferase activity  
    enables histone H2BK12 acetyltransferase activity  
    enables histone H2BK5 acetyltransferase activity  
    enables histone H3 acetyltransferase activity  
    enables histone H3K122 acetyltransferase activity  
    enables histone H3K14 acetyltransferase activity  
    enables histone H3K14 acetyltransferase activity  
    enables histone H3K14 acetyltransferase activity  
    enables histone H3K18 acetyltransferase activity  
    enables histone H3K23 acetyltransferase activity  
    enables histone H3K27 acetyltransferase activity  
    enables histone H3K36 acetyltransferase activity  
    enables histone H3K4 acetyltransferase activity  
    enables histone H3K56 acetyltransferase activity  
    enables histone H3K9 acetyltransferase activity  
    enables histone H3K9 acetyltransferase activity  
    enables histone H4K12 acetyltransferase activity  
    enables histone H4K12 acetyltransferase activity  
    enables histone H4K16 acetyltransferase activity  
    enables histone H4K16 acetyltransferase activity  
    enables histone H4K5 acetyltransferase activity  
    enables histone H4K5 acetyltransferase activity  
    enables histone H4K5 acetyltransferase activity  
    enables histone H4K8 acetyltransferase activity  
    enables histone H4K8 acetyltransferase activity  
    enables histone acetyltransferase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta morphogenesis  
    involved_in cellular senescence  
    involved_in cellular senescence  
    involved_in cellular senescence  
    acts_upstream_of_or_within embryonic hemopoiesis  
    acts_upstream_of_or_within face morphogenesis  
    acts_upstream_of_or_within heart morphogenesis  
    involved_in myeloid cell differentiation  
    involved_in myeloid cell differentiation  
    involved_in myeloid cell differentiation  
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in nucleosome assembly  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of gene expression PubMed 
    involved_in protein acetylation  
    involved_in protein acetylation  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within somatic stem cell population maintenance  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex  
    part_of MOZ/MORF histone acetyltransferase complex  
    part_of MOZ/MORF histone acetyltransferase complex  
    part_of MOZ/MORF histone acetyltransferase complex  
    located_in PML body  
    located_in PML body  
    located_in PML body  
    located_in chromatin  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleolus  
    located_in nucleolus  
    part_of nucleosome  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    histone acetyltransferase KAT6A
    Names
    K(lysine) acetyltransferase 6A
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
    MYST histone acetyltransferase (monocytic leukemia) 3
    MYST protein 3
    MYST-3
    histone acetyltransferase MYST3
    monocytic leukemia zinc finger homolog
    monocytic leukemia zinc finger protein
    NP_001094040.1
    XP_038950514.1
    XP_038950515.1
    XP_063131525.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100570.4NP_001094040.1  histone acetyltransferase KAT6A

      See identical proteins and their annotated locations for NP_001094040.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5TKR9
      UniProtKB/TrEMBL
      A0A0G2K1C6, A6IW49
      Related
      ENSRNOP00000071789.2, ENSRNOT00000078743.3
      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:502776
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      75787411..75868584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094586.2XP_038950514.1  histone acetyltransferase KAT6A isoform X1

      UniProtKB/Swiss-Prot
      Q5TKR9
      UniProtKB/TrEMBL
      A0A0G2K1C6, A6IW49
      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:502776
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    2. XM_039094587.2XP_038950515.1  histone acetyltransferase KAT6A isoform X1

      UniProtKB/Swiss-Prot
      Q5TKR9
      UniProtKB/TrEMBL
      A0A0G2K1C6, A6IW49
      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:502776
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    3. XM_063275455.1XP_063131525.1  histone acetyltransferase KAT6A isoform X2

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