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    Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29708, updated on 4-Jan-2025

    Summary

    Official Symbol
    Gabra6provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit alpha6provided by RGD
    Primary source
    RGD:61861
    See related
    EnsemblRapid:ENSRNOG00000003569 AllianceGenome:RGD:61861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables diazepam binding activity; heterocyclic compound binding activity; and inhibitory extracellular ligand-gated monoatomic ion channel activity. Contributes to GABA-A receptor activity; GABA-gated chloride ion channel activity; and benzodiazepine receptor activity. Involved in GABAergic synaptic transmission and response to ethanol. Located in dendrite; neuronal cell body membrane; and synaptic membrane. Part of receptor complex. Is active in several cellular components, including cerebellar Golgi cell to granule cell synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic specialization membrane. Used to study obesity. Orthologous to human GABRA6 (gamma-aminobutyric acid type A receptor subunit alpha6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 466.5) See more
    Orthologs
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    Genomic context

    See Gabra6 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (27311965..27327337, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (26810411..26825768, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27847447..27862896, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 1 Neighboring gene uncharacterized LOC108352216 Neighboring gene uncharacterized LOC134480630 Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 2 Neighboring gene uncharacterized LOC134480669

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to GABA-A receptor activity  
    contributes_to GABA-A receptor activity PubMed 
    enables GABA-A receptor activity  
    contributes_to GABA-gated chloride ion channel activity PubMed 
    contributes_to benzodiazepine receptor activity  
    contributes_to benzodiazepine receptor activity PubMed 
    contributes_to chloride channel activity  
    enables chloride channel activity  
    enables diazepam binding PubMed 
    enables heterocyclic compound binding PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity PubMed 
    enables protein-containing complex binding PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway PubMed 
    involved_in inhibitory synapse assembly  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of postsynaptic membrane potential  
    involved_in response to ethanol PubMed 
    involved_in synaptic transmission, GABAergic  
    involved_in synaptic transmission, GABAergic PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex  
    part_of GABA-A receptor complex  
    is_active_in GABA-ergic synapse PubMed 
    located_in GABA-ergic synapse  
    is_active_in cerebellar Golgi cell to granule cell synapse PubMed 
    located_in cerebellar Golgi cell to granule cell synapse  
    is_active_in cerebellar Golgi cell to granule cell synapse  
    part_of chloride channel complex  
    located_in dendrite PubMed 
    is_active_in dendrite membrane  
    is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
    located_in neuronal cell body membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in postsynapse  
    located_in postsynaptic membrane PubMed 
    is_active_in postsynaptic specialization membrane PubMed 
    located_in postsynaptic specialization membrane PubMed 
    located_in postsynaptic specialization membrane  
    located_in presynaptic membrane PubMed 
    part_of receptor complex PubMed 

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-6
    Names
    GABA(A) receptor subunit alpha-6
    GABA-A receptor alpha-6 subunit
    GABAAR subunit alpha-6
    gamma-aminobutyric acid (GABA) A receptor, alpha 6
    gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6
    gamma-aminobutyric acid A receptor, alpha 6
    gamma-aminobutyric acid type A receptor alpha 6 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021841.2NP_068613.2  gamma-aminobutyric acid receptor subunit alpha-6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P30191
      UniProtKB/TrEMBL
      A6HDL8, G3V6G3
      Related
      ENSRNOP00000004877.2, ENSRNOT00000004877.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      27311965..27327337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246128.5XP_006246190.1  gamma-aminobutyric acid receptor subunit alpha-6 isoform X1

      See identical proteins and their annotated locations for XP_006246190.1

      UniProtKB/Swiss-Prot
      P30191
      UniProtKB/TrEMBL
      A6HDL7
      Conserved Domains (3) summary
      TIGR00860
      Location:34430
      LIC; Cation transporter family protein
      pfam02931
      Location:33230
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:237427
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
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