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Lif leukemia inhibitory factor [ Mus musculus (house mouse) ]

Gene ID: 16878, updated on 13-Jan-2025

Summary

Official Symbol
Lifprovided by MGI
Official Full Name
leukemia inhibitory factorprovided by MGI
Primary source
MGI:MGI:96787
See related
Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; lung development; and positive regulation of macromolecule biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; early conceptus; hemolymphoid system; nervous system; and reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Lif in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4207587..4222514)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4257568..4272514)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11956 Neighboring gene STARR-seq mESC enhancer starr_28372 Neighboring gene oncostatin M Neighboring gene STARR-seq mESC enhancer starr_28375 Neighboring gene predicted gene 11959 Neighboring gene predicted gene 11958 Neighboring gene predicted gene, 53662

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables cytokine activity  
enables growth factor activity  
enables growth factor activity PubMed 
enables growth factor activity  
enables leukemia inhibitory factor receptor binding  
enables leukemia inhibitory factor receptor binding PubMed 
enables signaling receptor binding  
Items 1 - 25 of 67
Process Evidence Code Pubs
involved_in animal organ regeneration  
involved_in astrocyte differentiation  
acts_upstream_of_or_within blood vessel remodeling PubMed 
acts_upstream_of_or_within cell morphogenesis PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cell surface receptor signaling pathway via STAT  
involved_in cell surface receptor signaling pathway via STAT  
acts_upstream_of_or_within decidualization PubMed 
acts_upstream_of_or_within decidualization PubMed 
acts_upstream_of_or_within embryo implantation PubMed 
acts_upstream_of_or_within embryo implantation PubMed 
acts_upstream_of fibroblast proliferation PubMed 
acts_upstream_of_or_within gene expression PubMed 
involved_in immune response  
involved_in leukemia inhibitory factor signaling pathway  
involved_in leukemia inhibitory factor signaling pathway  
involved_in leukemia inhibitory factor signaling pathway  
acts_upstream_of_or_within lung alveolus development PubMed 
acts_upstream_of_or_within lung development PubMed 
acts_upstream_of_or_within lung lobe morphogenesis PubMed 
acts_upstream_of_or_within lung vasculature development PubMed 
acts_upstream_of_or_within maternal process involved in female pregnancy PubMed 
acts_upstream_of meiotic nuclear division PubMed 
acts_upstream_of_or_within muscle organ morphogenesis PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of angiogenesis  
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion  
acts_upstream_of_or_within negative regulation of meiotic nuclear division PubMed 
acts_upstream_of_or_within neuron development PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade  
acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
involved_in positive regulation of cell adhesion mediated by integrin  
involved_in positive regulation of cell adhesion mediated by integrin  
involved_in positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of corticotropin secretion  
acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
acts_upstream_of_or_within positive regulation of gene expression PubMed 
acts_upstream_of_or_within positive regulation of macrophage differentiation  
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
involved_in positive regulation of neuron projection development  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of receptor signaling pathway via STAT  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding PubMed 
involved_in regulation of cell differentiation  
acts_upstream_of_or_within regulation of cell differentiation PubMed 
involved_in regulation of metanephric nephron tubule epithelial cell differentiation  
involved_in regulation of metanephric nephron tubule epithelial cell differentiation  
acts_upstream_of_or_within response to hypoxia PubMed 
involved_in retina development in camera-type eye  
acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
acts_upstream_of_or_within spongiotrophoblast differentiation PubMed 
acts_upstream_of_or_within stem cell differentiation PubMed 
involved_in transdifferentiation  
acts_upstream_of_or_within trophoblast giant cell differentiation PubMed 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
Items 1 - 25 of 67
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
leukemia inhibitory factor
Names
d factor
differentiation-stimulating factor
myeloid leukaemia inhibitory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039537.3NP_001034626.1  leukemia inhibitory factor isoform b

    See identical proteins and their annotated locations for NP_001034626.1

    Status: VALIDATED

    Source sequence(s)
    AL731658
    Consensus CDS
    CCDS24384.1
    UniProtKB/TrEMBL
    F8WH42
    Related
    ENSMUSP00000036853.4, ENSMUST00000040750.4
    Conserved Domains (1) summary
    smart00080
    Location:1147
    LIF_OSM; leukemia inhibitory factor
  2. NM_001412335.1NP_001399264.1  leukemia inhibitory factor isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL731658
    UniProtKB/Swiss-Prot
    P09056
    UniProtKB/TrEMBL
    Q3U1H5
  3. NM_008501.3NP_032527.1  leukemia inhibitory factor isoform a precursor

    See identical proteins and their annotated locations for NP_032527.1

    Status: VALIDATED

    Source sequence(s)
    AL731658
    Consensus CDS
    CCDS24383.1
    UniProtKB/Swiss-Prot
    P09056
    UniProtKB/TrEMBL
    Q3U1H5
    Related
    ENSMUSP00000067066.6, ENSMUST00000066283.12
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4207587..4222514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514542.5XP_006514605.1  leukemia inhibitory factor isoform X1

    See identical proteins and their annotated locations for XP_006514605.1

    UniProtKB/Swiss-Prot
    P09056
    UniProtKB/TrEMBL
    Q3U1H5
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor
  2. XM_006514543.5XP_006514606.1  leukemia inhibitory factor isoform X1

    See identical proteins and their annotated locations for XP_006514606.1

    UniProtKB/Swiss-Prot
    P09056
    UniProtKB/TrEMBL
    Q3U1H5
    Conserved Domains (1) summary
    smart00080
    Location:35192
    LIF_OSM; leukemia inhibitory factor
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