U.S. flag

An official website of the United States government

SIGLEC8 sialic acid binding Ig like lectin 8 [ Homo sapiens (human) ]

Gene ID: 27181, updated on 4-Jan-2025

Summary

Official Symbol
SIGLEC8provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 8provided by HGNC
Primary source
HGNC:HGNC:10877
See related
Ensembl:ENSG00000105366 MIM:605639; AllianceGenome:HGNC:10877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAF2; SIGLEC-8; SIGLEC8L
Summary
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
Expression
Broad expression in lymph node (RPKM 2.6), spleen (RPKM 2.6) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SIGLEC8 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51450997..51458454, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54539617..54547074, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51954251..51961708, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NIFK pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51912204-51912704 Neighboring gene sialic acid binding Ig like lectin 10 Neighboring gene SIGLEC10 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15018 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51941886-51942056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51966471-51967219 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene Neighboring gene sialic acid binding Ig like lectin 26, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • MGC59785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding  
enables protein binding PubMed 
enables sialic acid binding  
enables transmembrane signaling receptor activity PubMed 
Process Evidence Code Pubs
involved_in cell adhesion  
involved_in signal transduction PubMed 
Component Evidence Code Pubs
located_in membrane PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 8
Names
CDw329
SAF-2
sialoadhesin family member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363548.1NP_001350477.1  sialic acid-binding Ig-like lectin 8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AF195092, BC053319, BP309940, DA388103
    Consensus CDS
    CCDS86797.1
    UniProtKB/TrEMBL
    C9JT30
    Related
    ENSP00000339448.4, ENST00000340550.5
    Conserved Domains (2) summary
    smart00410
    Location:176251
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain
  2. NM_014442.3NP_055257.2  sialic acid-binding Ig-like lectin 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055257.2

    Status: VALIDATED

    Source sequence(s)
    AF195092, BC053319, DA388103
    Consensus CDS
    CCDS33086.1
    UniProtKB/Swiss-Prot
    Q7Z728, Q9NYZ4
    Related
    ENSP00000321077.2, ENST00000321424.7
    Conserved Domains (3) summary
    smart00408
    Location:275335
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:269344
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51450997..51458454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526734.3XP_011525036.1  sialic acid-binding Ig-like lectin 8 isoform X1

    Conserved Domains (3) summary
    smart00408
    Location:264324
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:258333
    IG_like; Immunoglobulin like
    cl11960
    Location:27151
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54539617..54547074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320571.1XP_054176546.1  sialic acid-binding Ig-like lectin 8 isoform X1

External link. Please review our privacy policy.