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Il6st interleukin 6 signal transducer [ Mus musculus (house mouse) ]

Gene ID: 16195, updated on 14-Jan-2025

Summary

Official Symbol
Il6stprovided by MGI
Official Full Name
interleukin 6 signal transducerprovided by MGI
Primary source
MGI:MGI:96560
See related
Ensembl:ENSMUSG00000021756 AllianceGenome:MGI:96560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD130; gp130; D13Ertd699e; 5133400A03Rik
Summary
Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary immunodeficiency disease. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 57.5), subcutaneous fat pad adult (RPKM 32.9) and 24 other tissues See more
Orthologs
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Genomic context

See Il6st in Genome Data Viewer
Location:
13 D2.2; 13 63.73 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112600604..112643394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112464070..112506860)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 55 Neighboring gene predicted gene, 48837 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113188373-113188674 Neighboring gene STARR-seq mESC enhancer starr_35690 Neighboring gene STARR-seq mESC enhancer starr_35691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113214843-113215211 Neighboring gene predicted gene, 33905 Neighboring gene STARR-positive B cell enhancer mm9_chr13:113223673-113223974 Neighboring gene STARR-positive B cell enhancers ABC_E5418 and ABC_E4097 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113229709-113229897 Neighboring gene STARR-positive B cell enhancer ABC_E1890 Neighboring gene STARR-positive B cell enhancer ABC_E8545 Neighboring gene STARR-seq mESC enhancer starr_35693 Neighboring gene interleukin 31 receptor A Neighboring gene tubulin, alpha 1B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 30
Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor activity  
enables ciliary neurotrophic factor receptor binding  
enables ciliary neurotrophic factor receptor binding  
enables coreceptor activity  
enables coreceptor activity  
enables cytokine binding  
enables cytokine receptor activity  
contributes_to growth factor binding  
enables growth factor binding  
enables identical protein binding  
enables identical protein binding  
contributes_to interleukin-11 binding PubMed 
contributes_to interleukin-11 receptor activity PubMed 
contributes_to interleukin-6 binding  
enables interleukin-6 binding  
contributes_to interleukin-6 binding  
contributes_to interleukin-6 receptor activity  
enables interleukin-6 receptor activity  
contributes_to interleukin-6 receptor activity  
enables interleukin-6 receptor binding  
contributes_to interleukin-6 receptor binding  
enables leukemia inhibitory factor receptor activity  
contributes_to leukemia inhibitory factor receptor activity  
enables oncostatin-M receptor activity  
contributes_to oncostatin-M receptor activity  
enables protein binding PubMed 
enables protein tyrosine kinase activator activity  
enables protein tyrosine kinase activator activity  
enables scaffold protein binding  
enables scaffold protein binding  
Items 1 - 25 of 30
Items 1 - 25 of 39
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via STAT  
involved_in ciliary neurotrophic factor-mediated signaling pathway  
involved_in ciliary neurotrophic factor-mediated signaling pathway  
involved_in cytokine-mediated signaling pathway  
acts_upstream_of_or_within cytokine-mediated signaling pathway PubMed 
involved_in cytokine-mediated signaling pathway  
acts_upstream_of_or_within glycogen metabolic process PubMed 
involved_in interleukin-11-mediated signaling pathway  
involved_in interleukin-11-mediated signaling pathway  
involved_in interleukin-27-mediated signaling pathway  
involved_in interleukin-27-mediated signaling pathway  
involved_in interleukin-6-mediated signaling pathway PubMed 
involved_in interleukin-6-mediated signaling pathway  
involved_in intestinal epithelial cell development PubMed 
involved_in intestinal epithelial cell development  
involved_in leukemia inhibitory factor signaling pathway  
involved_in leukemia inhibitory factor signaling pathway  
involved_in negative regulation of cytosolic calcium ion concentration  
involved_in negative regulation of interleukin-6-mediated signaling pathway  
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of neuron apoptotic process  
involved_in oncostatin-M-mediated signaling pathway  
involved_in oncostatin-M-mediated signaling pathway  
involved_in positive regulation of Notch signaling pathway PubMed 
involved_in positive regulation of Notch signaling pathway  
involved_in positive regulation of T cell proliferation  
involved_in positive regulation of T cell proliferation  
acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
involved_in positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
acts_upstream_of_or_within regulation of Notch signaling pathway PubMed 
involved_in response to cytokine  
acts_upstream_of_or_within signal transduction PubMed 
involved_in triglyceride mobilization  
Items 1 - 25 of 39
Component Evidence Code Pubs
located_in cell body PubMed 
part_of ciliary neurotrophic factor receptor complex  
part_of ciliary neurotrophic factor receptor complex  
located_in dendrite PubMed 
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in extracellular space  
part_of interleukin-6 receptor complex  
part_of interleukin-6 receptor complex  
located_in membrane raft  
is_active_in membrane raft  
located_in neuronal cell body PubMed 
located_in neuronal cell body membrane  
part_of oncostatin-M receptor complex  
part_of oncostatin-M receptor complex  
is_active_in plasma membrane  
part_of receptor complex  

General protein information

Preferred Names
interleukin-6 receptor subunit beta
Names
IL-6 receptor subunit beta
IL-6R subunit beta
IL-6R-beta
IL-6RB
membrane glycoprotein 130
oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010560.3NP_034690.3  interleukin-6 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_034690.3

    Status: VALIDATED

    Source sequence(s)
    BC058679, BU709006, CJ177012, CV556562
    Consensus CDS
    CCDS26773.1
    UniProtKB/Swiss-Prot
    G5E8D2, Q00560
    UniProtKB/TrEMBL
    H6WCS3, Q6PDI9
    Related
    ENSMUSP00000138836.2, ENSMUST00000183663.8
    Conserved Domains (4) summary
    smart00060
    Location:521597
    FN3; Fibronectin type 3 domain
    cd00063
    Location:220319
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:125213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    112600604..112643394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157858.1XP_036013751.1  interleukin-6 receptor subunit beta isoform X1

    UniProtKB/Swiss-Prot
    G5E8D2, Q00560
    UniProtKB/TrEMBL
    H6WCS3, Q6PDI9
    Conserved Domains (4) summary
    smart00060
    Location:521597
    FN3; Fibronectin type 3 domain
    cd00063
    Location:220319
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:26112
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:125213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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