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Ulk2 unc-51 like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 29869, updated on 13-Jan-2025

Summary

Official Symbol
Ulk2provided by MGI
Official Full Name
unc-51 like kinase 2provided by MGI
Primary source
MGI:MGI:1352758
See related
Ensembl:ENSMUSG00000004798 AllianceGenome:MGI:1352758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc51.2; mKIAA0623; A830085I22Rik
Summary
Enables protein serine/threonine kinase activity. Involved in autophagy and response to starvation. Acts upstream of or within several processes, including axonogenesis; negative regulation of collateral sprouting; and somatic sensory system development. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues See more
Orthologs
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Genomic context

See Ulk2 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61666424..61750754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61775598..61855334, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene A kinase anchor protein 10 Neighboring gene STARR-seq mESC enhancer starr_29689 Neighboring gene STARR-positive B cell enhancer ABC_E8413 Neighboring gene predicted gene, 23721

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 26
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in autophagosome assembly  
involved_in autophagy PubMed 
involved_in autophagy  
involved_in axon extension  
acts_upstream_of_or_within axon extension PubMed 
acts_upstream_of_or_within axon guidance PubMed 
involved_in chromatin remodeling  
acts_upstream_of collateral sprouting PubMed 
involved_in mitophagy  
involved_in negative regulation of collateral sprouting  
acts_upstream_of_or_within negative regulation of collateral sprouting PubMed 
involved_in piecemeal microautophagy of the nucleus  
involved_in protein autophosphorylation  
acts_upstream_of_or_within protein localization PubMed 
involved_in regulation of autophagy  
involved_in regulation of autophagy  
involved_in response to starvation  
involved_in response to starvation PubMed 
involved_in reticulophagy  
involved_in signal transduction  
acts_upstream_of_or_within somatic sensory system development PubMed 
Component Evidence Code Pubs
is_active_in autophagosome  
is_active_in cytoplasm  
located_in cytoplasmic vesicle membrane  
is_active_in cytosol  
is_active_in phagophore assembly site  
is_active_in phagophore assembly site membrane  
located_in phagophore assembly site membrane PubMed 
located_in phagophore assembly site membrane  

General protein information

Preferred Names
serine/threonine-protein kinase ULK2
Names
serine/threonine-protein kinase Unc51.2
NP_038909.3
XP_006533571.1
XP_006533572.1
XP_030101926.1
XP_036012644.1
XP_036012645.1
XP_036012646.1
XP_036012647.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013881.4NP_038909.3  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_038909.3

    Status: VALIDATED

    Source sequence(s)
    AK146620, AK148142, AV256860, BM124275
    Consensus CDS
    CCDS24820.1
    UniProtKB/Swiss-Prot
    Q80TV7, Q9QY01, Q9WTP4
    UniProtKB/TrEMBL
    Q3UG39
    Related
    ENSMUSP00000004920.4, ENSMUST00000004920.4
    Conserved Domains (3) summary
    smart00220
    Location:9271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8651030
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61666424..61750754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156753.1XP_036012646.1  serine/threonine-protein kinase ULK2 isoform X6

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:725912
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036156752.1XP_036012645.1  serine/threonine-protein kinase ULK2 isoform X5

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:725904
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036156751.1XP_036012644.1  serine/threonine-protein kinase ULK2 isoform X2

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    pfam12063
    Location:809988
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:2238
    PKc_like; Protein Kinases, catalytic domain
  4. XM_030246066.2XP_030101926.1  serine/threonine-protein kinase ULK2 isoform X4

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802984
    DUF3543; Domain of unknown function (DUF3543)
  5. XM_006533509.5XP_006533572.1  serine/threonine-protein kinase ULK2 isoform X3

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802973
    DUF3543; Domain of unknown function (DUF3543)
  6. XM_036156754.1XP_036012647.1  serine/threonine-protein kinase ULK2 isoform X7

    Conserved Domains (1) summary
    pfam12063
    Location:367546
    DUF3543; Domain of unknown function (DUF3543)
  7. XM_006533508.5XP_006533571.1  serine/threonine-protein kinase ULK2 isoform X1

    UniProtKB/TrEMBL
    Q3UG39
    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8481019
    DUF3543; Domain of unknown function (DUF3543)
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